Roque Luís, Duarte Noélia, Bronze Maria Rosário, Garcia Catarina, Alopaeus Julia, Molpeceres Jesus, Hagesaether Ellen, Tho Ingunn, Rijo Patrícia, Reis Catarina
a CBiOS , Universidade Lusófona de Humanidades e Tecnologias , Lisboa , Portugal.
b Department of Biomedical Sciences, Faculty of Pharmacy , University of Alcalá , Alcalá de Henares , Spain.
Biofouling. 2018 Sep;34(8):880-892. doi: 10.1080/08927014.2018.1514391. Epub 2018 Oct 26.
L. is considered an important source of bioactive compounds. This study aimed at the development of an efficient solution for the treatment of oral candidiasis. Several extracts of L. were prepared using different solvents and their potential antifungal activity was assessed. Ethanolic extracts showed the most promising results against This extract was incorporated into mucoadhesive nanoparticles (PLA, PLGA and alginate), which were further included in an oral gel, an oral film and a toothpaste, respectively. The results showed that nanoparticles were successfully produced, presenting a mean size among 100-900 nm with high encapsulation efficiency. studies showed that the most bioadhesive formulation was the oral film with extract-loaded PLGA nanoparticles, followed by the toothpaste with extract-loaded alginate nanoparticles and the oral gel with extract-loaded PLA nanoparticles.
L.被认为是生物活性化合物的重要来源。本研究旨在开发一种治疗口腔念珠菌病的有效解决方案。使用不同溶剂制备了几种L.的提取物，并评估了它们潜在的抗真菌活性。乙醇提取物对……显示出最有前景的结果。该提取物被纳入粘膜粘附纳米颗粒（聚乳酸、聚乳酸-羟基乙酸共聚物和藻酸盐），这些纳米颗粒分别进一步包含在口腔凝胶、口腔膜和牙膏中。结果表明成功制备了纳米颗粒，其平均尺寸在100 - 900纳米之间，具有高包封率。研究表明，生物粘附性最强的制剂是载有提取物的聚乳酸-羟基乙酸共聚物纳米颗粒的口腔膜，其次是载有提取物的藻酸盐纳米颗粒的牙膏和载有提取物的聚乳酸纳米颗粒的口腔凝胶。
