Khozeimeh Faezeh, Dehghan Parvin, Yaghoobi Negin, Maheronnaghsh Mehrnoush, Bazazzadeh Mona, Noorbakhsh Seyedeh Negin
Dental Research Center, Department of Oral Medicine, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Tehran, Iran.
Dent Res J (Isfahan). 2022 Aug 16;19:61. eCollection 2022.
Oral candidiasis is one of the most common manifestations of patients with cancer under chemotherapy. Due to many side effects of chemical antifungal products and various advantages of herbal extracts like licorice, this study was performed to compare the antifungal effects of nystatin and licorice on yeasts isolated from oral mucosa of patients with cancer receiving chemotherapy.
In this study, a total number of 30 patients with oral candidiasis who received chemotherapy were examined. The samples were prepared by using swabs taken from the lesions, and after 48 h, they were transferred and cultured on Sabouraud dextrose agar. The antifungal effect of licorice was compared with nystatin using agar disk diffusion method. These data were entered in SPSS statistical software and were analyzed with Kruskal-Wallis and Mann-Whitney tests. (α = 5%).
Four types of candida were identified among all 30 oral lesions (). The mean inhibition zone diameter around nystatin showed a significant difference ( < 0.001) between (9.486), C. (8.627), (7.00), and (7.06) but the inhibition zone diameter around licorice was almost zero in all groups.
Licorice extracts did not show any antifungal effects whereas nystatin showed the most antifungal effect against .
口腔念珠菌病是癌症化疗患者最常见的表现之一。由于化学抗真菌产品存在诸多副作用，以及甘草等草药提取物具有多种优势，本研究旨在比较制霉菌素和甘草对从接受化疗的癌症患者口腔黏膜分离出的酵母菌的抗真菌效果。
本研究共检查了30例接受化疗的口腔念珠菌病患者。通过从病变部位采集拭子制备样本，48小时后，将其转移至沙氏葡萄糖琼脂培养基上进行培养。采用琼脂扩散法比较甘草与制霉菌素的抗真菌效果。这些数据录入SPSS统计软件，并用Kruskal-Wallis和Mann-Whitney检验进行分析（α = 5%）。
在所有30个口腔病变样本中鉴定出四种念珠菌。制霉菌素周围的平均抑菌圈直径在白色念珠菌（9.486）、热带念珠菌（8.627）、近平滑念珠菌（7.00）和光滑念珠菌（7.06）之间显示出显著差异（P < 0.001），但甘草周围的抑菌圈直径在所有组中几乎为零。
甘草提取物未显示出任何抗真菌作用，而制霉菌素对白色念珠菌显示出最强的抗真菌作用。
