Brandtzaeg P, Nilssen D E, Rognum T O, Thrane P S
University of Oslo, Norway.
Gastroenterol Clin North Am. 1991 Sep;20(3):397-439.
Studies of ontogenesis contribute to better understanding of regulatory events underlying the striking heterogeneity in B-cell differentiation pathways employed in the human mucosal immune system. This disparity is probably explained by exogenous environmental factors, although regional differences probably also exist in accessory cells and cytokines involved in local immune responses. IgA deficiency signifies a heterogeneous syndrome but is basically a manifestation of a defect in B-cell differentiation. The immaturity of the IgA system revealed in this disorder bears a striking resemblance to that seen in newborn infants. It may therefore be worthwhile to consider IgA deficiency in relation to the ontogeny of mucosal immunity.
个体发生学的研究有助于更好地理解人类黏膜免疫系统中B细胞分化途径显著异质性背后的调控事件。这种差异可能由外源性环境因素解释，尽管在参与局部免疫反应的辅助细胞和细胞因子中可能也存在区域差异。IgA缺乏症是一种异质性综合征，但基本上是B细胞分化缺陷的表现。这种疾病中揭示的IgA系统不成熟与新生儿中所见的情况极为相似。因此，考虑IgA缺乏症与黏膜免疫个体发生的关系可能是值得的。
