双相情感障碍患者的大脑γ-氨基丁酸水平
Brain GABA levels in patients with bipolar disorder.
作者信息
Kaufman Rebecca E, Ostacher Michael J, Marks Elizabeth H, Simon Naomi M, Sachs Gary S, Jensen J Eric, Renshaw Perry F, Pollack Mark H
机构信息
Massachusetts General Hospital Department of Psychiatry, Boston, MA 02114, United States.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):427-34. doi: 10.1016/j.pnpbp.2008.12.025. Epub 2009 Jan 10.
PURPOSE
A growing body of research supports an important role for GABA in the pathophysiology of bipolar and other mood disorders. The purpose of the current study was to directly examine brain GABA levels in a clinical sample of bipolar patients.
GENERAL METHODS
We used magnetic resonance spectroscopy (MRS) to examine whole brain and regional GABA, glutamate and glutamine in 13 patients with bipolar disorder compared to a matched group of 11 healthy controls.
FINDINGS
There were no significant differences in GABA, glutamate or glutamine between patients and controls.
CONCLUSIONS
Further research is needed to better characterize the GABAergic and glutamatergic effects of pharmacotherapy, anxiety comorbidity and clinical state in bipolar disorder.
目的
越来越多的研究支持γ-氨基丁酸（GABA）在双相情感障碍和其他情绪障碍的病理生理学中起重要作用。本研究的目的是直接检测双相情感障碍患者临床样本中的脑内GABA水平。
一般方法
我们使用磁共振波谱（MRS）检测了13例双相情感障碍患者全脑及局部的GABA、谷氨酸和谷氨酰胺水平，并与11名匹配的健康对照者进行比较。
研究结果
患者与对照者之间的GABA、谷氨酸或谷氨酰胺水平无显著差异。
结论
需要进一步研究以更好地描述双相情感障碍中药物治疗、焦虑共病和临床状态对GABA能和谷氨酸能的影响。
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