Atagün Murat İlhan, Şıkoğlu Elif Muazzez, Soykan Çağlar, Serdar Süleyman Can, Ulusoy-Kaymak Semra, Çayköylü Ali, Algın Oktay, Phillips Mary Louise, Öngür Dost, Moore Constance Mary
Department of Psychiatry, Ankara Yıldırım Beyazıt University Medical School, Ankara, Turkey; Department of Psychiatry, Ankara Ataturk Training and Education Hospital, Ankara, Turkey.
Department of Psychiatry, University of Massachusetts Memorial Medical School, Memorial Campus 119 Belmont Street, Worcester, MA 01605, USA.
Neurosci Lett. 2017 Jan 10;637:70-74. doi: 10.1016/j.neulet.2016.11.051. Epub 2016 Nov 24.
The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). H-MRS data was acquired using a Siemens 3T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [χ=9.62, df: 3, p=0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r=0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder.
本研究旨在利用质子磁共振波谱（H-MRS）测量精神分裂症和双相情感障碍患者颞周皮质的γ-氨基丁酸（GABA）水平。将精神分裂症患者（n = 25）、双相I型障碍（BD-I；n = 28）和双相II型障碍（BD-II；n = 20）患者与健康对照者（n = 30）进行比较。使用西门子3T全身扫描仪获取H-MRS数据，以量化左右颞周结构（包括颞上叶）的GABA水平。各组之间右侧颞周GABA值存在显著差异[χ=9.62，自由度：3，p = 0.022]。与健康对照组相比，精神分裂症组的GABA水平显著更高（p = 0.002）。此外，抗精神病药物的氯丙嗪等效剂量与右侧半球GABA水平相关（r = 0.68，p = 0.006，n = 33）。与双相情感障碍患者和健康对照者相比，精神分裂症患者右侧半球的GABA水平升高。皮质回路兴奋和抑制控制之间的平衡可能与听觉皮质中的GABA能功能有直接关系。此外，GABA水平可能会因精神分裂症和双相情感障碍患者的感兴趣脑区、精神药物和临床阶段而改变。
