Bhat Yasmeen J, Manzoor Sheikh, Khan A R, Qayoom Seema
Department of Dermatology, STD and Leprosy, SKIMS Medical College Hospital, Bemina, Srinagar, India.
Indian J Dermatol Venereol Leprol. 2009 Jan-Feb;75(1):29-31. doi: 10.4103/0378-6323.45216.
Alopecia areata (AA) is a recurrent, nonscarring type of hair loss considered to be an autoimmune process. Though its etiopathology is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA.
The aim of the present study was to assess the levels of zinc, copper, and magnesium in the serum of AA patients.
Fifty AA patients (34 men and 16 women), and fifty age and sex matched healthy control subjects were studied. Samples were analyzed using atomic absorption spectrometric methods.
Serum zinc levels were significantly decreased (P < 0.05) in AA patients whose disease was extensive, prolonged, and resistant to treatment, whereas serum copper and magnesium levels showed insignificant rise compared to controls.
We conclude that copper and magnesium levels are not altered in AA, but the decreased zinc levels found in our study may merit further investigation of the relationship.
斑秃（AA）是一种复发性、非瘢痕性脱发，被认为是一种自身免疫过程。尽管其病因病理尚未完全明确，但有观点认为微量元素失衡可能引发斑秃的发病。
本研究旨在评估斑秃患者血清中锌、铜和镁的水平。
对50例斑秃患者（34例男性和16例女性）以及50例年龄和性别匹配的健康对照者进行研究。采用原子吸收光谱法对样本进行分析。
病情广泛、病程延长且对治疗有抵抗性的斑秃患者血清锌水平显著降低（P < 0.05），而血清铜和镁水平与对照组相比虽有升高但不显著。
我们得出结论，斑秃患者的铜和镁水平未发生改变，但本研究中发现的锌水平降低可能值得进一步研究两者之间的关系。
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