Akinloye O, Adebayo T O, Oguntibeju O O, Oparinde D P, Ogunyemi E O
Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa.
West Indian Med J. 2011 Jun;60(3):308-15.
Women on different contraceptive methods have been linked with the development of various diseases and possible changes in serum trace elements and vitamins of women on contraceptives have been postulated. Therefore, the relationship between contraceptive use and trace elements needs to be investigated.
This is a cross-sectional randomized study. After informed consent was obtained, blood samples were collected from a total of 100 women of child-bearing age on different contraceptive methods: 50 on oral contraceptives, 25 on injectables and another 25 on intra-uterine device. Blood samples were also collected from another 50 age-matched non-contraceptive users to serve as control. Serum was analysed using atomic absorption spectrophotometer for zinc, copper manganese, iron, selenium, cadmium, lead and magnesium while colorimetric method was used for phosphorus and calcium. Body mass index (BMI) was calculated as weight in kilogram/height in meter squared. Results obtained from laboratory analysis and anthropometric measurements were analysed using computer SPSS package.
The mean serum zinc, selenium, phosphorus and magnesium levels obtained from subjects on contraceptives were significantly lower (p < 0.01, p < 0.05, p < 0.05 and p < 0.05 respectively) than those of the control group. However, the mean serum copper iron, calcium and cadmium levels were significantly higher (p < 0.05) in participants on contraceptive when compared with the control group. Manganese and lead levels were similar in participants and control groups. Correlation analysis shows significant association between some trace elements and the duration of contraception and body mass index of the participants.
The study showed and confirmed reduced levels of trace elements in women on contraceptives. The reduction is proportional to the duration of contraceptive use.
采用不同避孕方法的女性与各种疾病的发生有关，并且推测使用避孕药的女性血清微量元素和维生素可能会发生变化。因此，需要研究避孕方法的使用与微量元素之间的关系。
这是一项横断面随机研究。在获得知情同意后，从总共100名处于不同避孕方法的育龄妇女中采集血样：50名使用口服避孕药，25名使用注射剂，另外25名使用宫内节育器。还从另外50名年龄匹配的未使用避孕药的女性中采集血样作为对照。使用原子吸收分光光度计分析血清中的锌、铜、锰、铁、硒、镉、铅和镁，而使用比色法分析磷和钙。体重指数（BMI）计算为体重（千克）除以身高（米）的平方。使用计算机SPSS软件包分析实验室分析和人体测量结果。
使用避孕药的受试者的血清锌、硒、磷和镁的平均水平显著低于对照组（分别为p < 0.01、p < 0.05、p < 0.05和p < 0.05）。然而，与对照组相比，使用避孕药的参与者的血清铜、铁、钙和镉的平均水平显著更高（p < 0.05）。锰和铅水平在参与者和对照组中相似。相关性分析表明，一些微量元素与避孕持续时间和参与者的体重指数之间存在显著关联。
该研究表明并证实了使用避孕药的女性体内微量元素水平降低。这种降低与避孕使用时间成正比。
