Zargar A H, Shah N A, Masoodi S R, Laway B A, Dar F A, Khan A R, Sofi F A, Wani A I
Department of Endocrinology, Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Postgrad Med J. 1998 Nov;74(877):665-8. doi: 10.1136/pgmj.74.877.665.
A relationship has been reported between trace elements and diabetes mellitus. This study evaluated the role of such a relationship in 83 patients with non-insulin dependent diabetes mellitus (40 men and 43 women), with a mean duration of diabetes of 3.9 +/- 3.6 years. Patients with nephropathy were excluded. Thirty healthy non-diabetic subjects were studied for comparative analysis. Subjects were subdivided into obese and non-obese. Diabetic subjects were also subdivided into controlled and uncontrolled groups; control was based on fasting blood glucose and serum fructosamine levels. Plasma copper, zinc and magnesium levels were analysed using a GBC 902 double beam atomic absorption spectrophotometer. Plasma zinc and magnesium levels were comparable between diabetic and non-diabetic subjects, while copper levels were significantly elevated (p < 0.01) in diabetic patients. Age, sex, duration and control of diabetes did not influence copper, zinc, or magnesium concentrations. We conclude that zinc and magnesium levels are not altered in diabetes mellitus, but the increased copper levels found in diabetics in our study may merit further investigation of the relationship between copper and non-insulin dependent diabetes mellitus.
据报道，微量元素与糖尿病之间存在关联。本研究评估了这种关联在83例非胰岛素依赖型糖尿病患者（40名男性和43名女性）中的作用，这些患者的糖尿病平均病程为3.9±3.6年。排除了患有肾病的患者。选取30名健康非糖尿病受试者进行对比分析。受试者被分为肥胖组和非肥胖组。糖尿病受试者也被分为血糖控制组和未控制组；控制标准基于空腹血糖和血清果糖胺水平。使用GBC 902双光束原子吸收分光光度计分析血浆铜、锌和镁水平。糖尿病患者和非糖尿病受试者的血浆锌和镁水平相当，而糖尿病患者的铜水平显著升高（p<0.01）。年龄、性别、糖尿病病程和控制情况均不影响铜、锌或镁的浓度。我们得出结论，糖尿病患者的锌和镁水平未发生改变，但在我们的研究中糖尿病患者发现的铜水平升高可能值得进一步研究铜与非胰岛素依赖型糖尿病之间的关系。
