Wyler Stephen Frederic, Engeler Daniel Stephan, Seelentag Wolfhart, Ries Gerhard, Schmid Hans-Peter
Department of Urology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Urol Int. 2009;82(1):17-23. doi: 10.1159/000176019. Epub 2009 Jan 20.
To evaluate quality of life (QOL) after radical retropubic prostatectomy (RP) and low-dose-rate brachytherapy (BT).
Between 2001 and 2004, RP or BT was performed in 212 patients. QOL data were evaluated with the European Organization for Research and Treatment of Cancer QLQ-C30 version 3.0, the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function-5 questionnaires. QOL data were compared.
RP and BT were performed in 142 and 70 patients, respectively. The mean follow-up was 24 months (5-53). The mean overall global health score for patients after RP was 78 (0-100) and after BT it was 83 (33-100), and it showed a trend in favour of BT. The follow-up lasted at most 53 months, and the period was divided into yearly categories. Patients who underwent BT showed worse global health in the first year after operation, but thereafter they showed better health. Patients who received BT showed a trend towards having lower functional-scale and symptom-scale scores in the first year after operation, and then higher scores for any subsequent year of follow-up. Only diarrhoea was temporarily worse in the second year after BT compared to RP. The mean total IPSS and QOL score for BT and RP patients during follow-up showed no significant difference.
Patients treated with BT or RP have similar QOL scores. QOL after BT is worse in the first year after treatment, but thereafter it is better than QOL after RP.
评估耻骨后根治性前列腺切除术（RP）和低剂量率近距离放射治疗（BT）后的生活质量（QOL）。
2001年至2004年间，对212例患者实施了RP或BT。使用欧洲癌症研究与治疗组织QLQ-C30第3.0版、国际前列腺症状评分（IPSS）和国际勃起功能指数-5问卷对生活质量数据进行评估。对生活质量数据进行比较。
分别对142例和70例患者实施了RP和BT。平均随访时间为24个月（5 - 53个月）。RP术后患者的平均总体健康评分为78（0 - 100），BT术后为83（33 - 100），显示出有利于BT的趋势。随访最长持续53个月，并按年份分类。接受BT的患者在术后第一年的总体健康状况较差，但此后有所改善。接受BT的患者在术后第一年的功能量表和症状量表评分有降低的趋势，而在随后的任何一年随访中评分较高。与RP相比，仅BT术后第二年腹泻情况暂时更严重。随访期间BT和RP患者的平均IPSS总分和生活质量评分无显著差异。
接受BT或RP治疗的患者生活质量评分相似。BT治疗后第一年的生活质量较差，但此后优于RP治疗后的生活质量。
