Department of General Surgery, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.
Surg Endosc. 2009 Oct;23(10):2292-5. doi: 10.1007/s00464-008-0314-1. Epub 2009 Jan 27.
Patients with gastroesophageal reflux disease (GERD) and abnormal esophageal motility are the most controversial subgroup of surgically treated patients because of potentially increased risk of postoperative dysphagia. Our study aim was to determine if Nissen fundoplication is associated with increased postoperative dysphagia in patients with ineffective esophageal motility.
Medical records of all adult (>18 years old) patients who underwent laparoscopic Nissen fundoplication for GERD over 8 years were reviewed retrospectively. Of the 151 patients, 28 (group A) met manometric criteria for abnormal esophageal motility (<30 mmHg mean contractile pressure or <80% peristalsis), whereas 63 (group B) had normal esophageal function. Sixty patients had no manometric data and were therefore excluded from analysis. Follow-up time ranged from 1 month to 5 years. Outcomes (postoperative dysphagia, recurrence of GERD symptoms, free of medications) were compared between groups.
Group A had higher age and American Society of Anesthesiologists (ASA) score (p = 0.016 and 0.020), but this did not correlate with outcome. Two patients (7.1%) in group A and three patients (5.3%) in group B had postoperative dysphagia. When adjusted for follow-up time, there was no significant difference between the groups (p = 0.94). Group B had more cases of recurrent heartburn (10.7% versus 3.6%, p = 0.039), and more patients in this group were back on medications (21.4% versus 7.1%, p < 0.05)
This retrospective study found equally low rates of dysphagia following Nissen fundoplication regardless of baseline esophageal motility. Preoperative esophageal dysmotility therefore does not seem to be a contraindication for laparoscopic Nissen fundoplication.
胃食管反流病(GERD)和食管运动异常的患者是手术治疗患者中最具争议的亚组,因为术后吞咽困难的风险可能会增加。我们的研究目的是确定在无效食管动力的患者中,Nissen 胃底折叠术是否与术后吞咽困难的增加相关。
回顾性分析了 8 年来接受腹腔镜 Nissen 胃底折叠术治疗 GERD 的所有成年(>18 岁)患者的病历。在 151 例患者中,28 例(A 组)符合食管运动异常的测压标准(平均收缩压<30mmHg 或蠕动<80%),而 63 例(B 组)食管功能正常。60 例患者没有测压数据,因此被排除在分析之外。随访时间从 1 个月到 5 年不等。比较两组之间的结果(术后吞咽困难、GERD 症状复发、停药)。
A 组年龄和美国麻醉医师协会(ASA)评分较高(p=0.016 和 0.020),但与结果无关。A 组中有 2 例(7.1%)和 B 组中有 3 例(5.3%)患者术后出现吞咽困难。调整随访时间后,两组之间无显著差异(p=0.94)。B 组有更多的复发性烧心病例(10.7%比 3.6%,p=0.039),并且该组中有更多的患者需要服药(21.4%比 7.1%,p<0.05)。
这项回顾性研究发现,无论基线食管动力如何,Nissen 胃底折叠术后吞咽困难的发生率同样较低。因此,术前食管动力障碍似乎不是腹腔镜 Nissen 胃底折叠术的禁忌症。