Channing C P, Tsafriri A
Metabolism. 1977 Apr;26(4):413-68. doi: 10.1016/0026-0495(77)90108-1.
The mechanism of action of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) upon various cell types of the mammalian ovary is reviewed. Emphasis is placed upon in vitro studies using organ and cell culture as well as short-term incubations. FSH and LH actions upon the following ovarian functions are discussed: steroidogenesis and metabolism of the ovary as a whole and of the isolated follicle and its component cell types, the granulosa and thecal cells, as well as folliculogenesis and follicular growth, oocyte maturation, follicular rupture, and corpus luteum maintenance and steroidogenesis. The roles of gonadotropin receptors, AMP, prostaglandins, protein kinase, and protein synthesis in these LH and FSH actions are discussed. Intra-ovarian regulation of LH and FSH action is reviewed, including a discussion of the possible roles of follicular fluid inhibitors upon oocyte maturation and granulosa cell luteinization.
本文综述了促黄体生成素（LH）和促卵泡生成素（FSH）对哺乳动物卵巢各种细胞类型的作用机制。重点在于使用器官和细胞培养以及短期孵育的体外研究。讨论了FSH和LH对以下卵巢功能的作用：整个卵巢以及分离的卵泡及其组成细胞类型（颗粒细胞和卵泡膜细胞）的类固醇生成和代谢，以及卵泡发生和卵泡生长、卵母细胞成熟、卵泡破裂、黄体维持和类固醇生成。还讨论了促性腺激素受体、AMP、前列腺素、蛋白激酶和蛋白质合成在这些LH和FSH作用中的作用。综述了LH和FSH作用的卵巢内调节，包括讨论卵泡液抑制剂对卵母细胞成熟和颗粒细胞黄体化的可能作用。
