Jääskeläinen Jarmo, Korhonen Seija, Voutilainen Raimo, Hippeläinen Maritta, Heinonen Seppo
Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
Fertil Steril. 2005 Jun;83(6):1724-8. doi: 10.1016/j.fertnstert.2004.11.080.
To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS).
Retrospective case-control study.
University-based clinic.
PATIENT(S): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls.
INTERVENTION(S): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls.
MAIN OUTCOME MEASURE(S): Androgen receptor gene CAG repeat length in both groups.
RESULT(S): The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn < or =18, 19-24, > or =25), the distribution was similar in both groups (NS; chi2 test). However, all five women carrying < or =15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration.
CONCLUSION(S): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen-related diseases in some individuals.
确定雄激素受体（AR）基因的CAG重复长度是否导致多囊卵巢综合征（PCOS）易感性的个体差异。
回顾性病例对照研究。
大学附属医院门诊。
106例非糖尿病PCOS女性患者和112例无多毛症状的可育对照者。
分析PCOS女性患者及其对照者的雄激素受体基因CAG重复长度。
两组的雄激素受体基因CAG重复长度。
两组的平均CAGn重复数均为21.5次（无统计学差异；t检验）。此外，当将CAGn长度分为三类（CAGn≤18、19 - 24、≥25）时，两组的分布相似（无统计学差异；卡方检验）。然而，所有5例CAG重复数≤15次的女性均属于PCOS组。在PCOS组中，CAGn与体重指数或血清睾酮浓度无关。
雄激素受体CAGn不是PCOS的主要决定因素。然而，在某些个体中它可能是雄激素相关疾病的重要调节因子。
