He Huadong, Xie Bo, Xie Liping
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University Department of Urology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine Department of Urology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Medicine (Baltimore). 2018 Jul;97(28):e11379. doi: 10.1097/MD.0000000000011379.
The relationship between male pattern baldness and incidence of prostate cancer remains inconclusive. Hence, we performed the present meta-analysis based on all eligible cohort and case-control studies.
A comprehensive literature search was performed in October 2017 based on PubMed and Web of Science databases. Pooled relative risk (RR) and its 95% confidence interval (95% CI) was calculated with a DerSimonian and Laird random-effects model.
A total of 15 studies were included in this meta-analysis. Overall, no statistically significant association between baldness (any pattern) and prostate cancer risk was identified (RR: 1.03, 95% CI 0.96-1.11). There was obvious heterogeneity across included studies (P < .078 for heterogeneity, I = 36.4%). When subgroup analysis by types of baldness, a statistically significant association was observed for vertex baldness (RR 1.24, 95% CI 1.05-1.46) but not for other types of baldness.
Individuals with vertex baldness may have an increased risk of prostate cancer. Given the obvious heterogeneity and null results in overall analysis and most of subgroup analyses, further large well-designed prospective cohort studies are warranted to confirm our preliminary findings.
男性型秃发与前列腺癌发病率之间的关系尚无定论。因此，我们基于所有符合条件的队列研究和病例对照研究进行了本次荟萃分析。
2017年10月，我们基于PubMed和Web of Science数据库进行了全面的文献检索。采用DerSimonian和Laird随机效应模型计算合并相对风险（RR）及其95%置信区间（95%CI）。
本次荟萃分析共纳入15项研究。总体而言，未发现秃发（任何类型）与前列腺癌风险之间存在统计学显著关联（RR：1.03，95%CI 0.96 - 1.11）。纳入的研究之间存在明显的异质性（异质性P < 0.078，I = 36.4%）。按秃发类型进行亚组分析时，观察到头顶秃发存在统计学显著关联（RR 1.24，95%CI 1.05 - 1.46），但其他类型秃发未发现此类关联。
头顶秃发的个体可能患前列腺癌的风险增加。鉴于总体分析和大多数亚组分析中存在明显的异质性且结果为阴性，有必要进一步开展大规模、设计良好的前瞻性队列研究来证实我们的初步发现。
