一种用于磁共振成像引导药物递送的温度敏感型脂质体1H CEST和19F造影剂。

A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery.

作者信息

Langereis Sander, Keupp Jochen, van Velthoven Juliën L J, de Roos Inge H C, Burdinski Dirk, Pikkemaat Jeroen A, Grüll Holger

机构信息

Philips Research Europe, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands.

出版信息

J Am Chem Soc. 2009 Feb 4;131(4):1380-1. doi: 10.1021/ja8087532.

DOI:10.1021/ja8087532

PMID:19173663

Abstract

A novel temperature-sensitive liposomal MRI contrast agent has been developed, which allows drug carrier localization using (1)H CEST with simultaneous quantification of the drug release using (19)F MR imaging in response to a local temperature increase.

摘要

一种新型的温度敏感脂质体磁共振成像造影剂已被开发出来，它能够利用质子化学交换饱和转移（1H CEST）实现药物载体定位，并在局部温度升高时，通过氟磁共振成像（19F MR成像）同步定量药物释放情况。