Huang Jingxian, Huang Wenwei, Chen Yin, Zhang Yu Shrike, Zhong Jinshuang, Li Yan, Zhou Jianhua
School of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School 65 Landsdowne Street Cambridge Massachusetts 02139 USA.
RSC Adv. 2018 Dec 17;8(73):41956-41965. doi: 10.1039/c8ra08501c. eCollection 2018 Dec 12.
In this work, we present a novel class of uniform eccentric magnetic microcapsules based on polydimethylsiloxane (PDMS) for magnetic resonance imaging (MRI)-guided local injection and pH-regulated drug release. The microcapsules contained magnetic nanoparticles in their PDMS shells, which allowed them to be easily tracked by MRI during administration. Besides, they showed pH-dependent drug release profiles due to dissolution of the embedded magnetic nanoparticles in acidic solutions. Moreover, by tuning the mass fraction of the magnetic nanoparticles, we could further regulate the release rate of drug molecules from them. As a demonstration, we investigated the delivery of cis-platinum using the microcapsules through an cell test, which confirmed the pH-controlled release of the drug in phantom tissues. Our study suggests that this type of eccentric magnetic microcapsules could be simultaneously employed as a potential imaging contrast and a smart drug delivery system, holding great potential for guided local therapy.
在这项工作中，我们展示了一类新型的基于聚二甲基硅氧烷（PDMS）的均匀偏心磁性微胶囊，用于磁共振成像（MRI）引导下的局部注射和pH调节的药物释放。微胶囊在其PDMS壳层中含有磁性纳米颗粒，这使得它们在给药过程中能够被MRI轻松追踪。此外，由于嵌入的磁性纳米颗粒在酸性溶液中的溶解，它们表现出pH依赖性的药物释放曲线。而且，通过调节磁性纳米颗粒的质量分数，我们可以进一步调节药物分子从它们中的释放速率。作为一个实例，我们通过细胞测试研究了使用微胶囊递送顺铂的情况，这证实了药物在模拟组织中的pH控制释放。我们的研究表明，这种类型的偏心磁性微胶囊可以同时用作潜在的成像造影剂和智能药物递送系统，在引导局部治疗方面具有巨大潜力。
