Department of Chemistry IFM and Molecular & Preclinical Imaging Centres, University of Torino, via Nizza 52, 10126, Torino, Italy.
Chem Commun (Camb). 2011 Apr 28;47(16):4667-9. doi: 10.1039/c1cc10172b. Epub 2011 Mar 15.
A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.
本文描述了一类新型的顺磁脂质体基系统，可用作双重 T(1) 和 CEST (1)H-MRI 对比剂。这些囊泡在水核中包含一个位移试剂，在外部表面上则通过可生物降解的连接子连接一个 Gd 配合物。因此，该探针只能产生 T(1) 对比，但在去除 Gd 涂层并进行切割后，CEST 对比就会开启。
