Zhang Leiliang, Villa Nancy Y, McFadden Grant
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
FEBS Lett. 2009 Feb 18;583(4):607-14. doi: 10.1016/j.febslet.2009.01.023. Epub 2009 Jan 25.
Post-translational polypeptide tagging by conjugation with ubiquitin and ubiquitin-like (Ub/Ubl) molecules is a potent way to alter protein functions and/or sort specific protein targets to the proteasome for degradation. Many poxviruses interfere with the host Ub/Ubl system by encoding viral proteins that can usurp this pathway. Some of these include viral proteins of the membrane-associated RING-CH (MARCH) domain, p28/Really Interesting New Gene (RING) finger, ankyrin-repeat/F-box and Broad-complex, Tramtrack and Bric-a-Brac (BTB)/Kelch subgroups of the E3 Ub ligase superfamily. Here we describe and discuss the various strategies used by poxviruses to target and subvert the host cell Ub/Ubl systems.
通过与泛素及泛素样（Ub/Ubl）分子结合进行翻译后多肽标记，是改变蛋白质功能和/或将特定蛋白质靶标分选至蛋白酶体进行降解的有效方式。许多痘病毒通过编码可利用此途径的病毒蛋白来干扰宿主的Ub/Ubl系统。其中一些包括膜相关RING-CH（MARCH）结构域、p28/真核生物有趣新基因（RING）结构域、锚蛋白重复序列/F盒以及E3泛素连接酶超家族的Broad-complex、Tramtrack和Bric-a-Brac（BTB）/Kelch亚组的病毒蛋白。在此，我们描述并讨论痘病毒用于靶向和颠覆宿主细胞Ub/Ubl系统的各种策略。
