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Phosphorylation keeps PTEN phosphatase closed for business.

作者信息

Ross Alonzo H, Gericke Arne

机构信息

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

出版信息

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1297-8. doi: 10.1073/pnas.0812473106. Epub 2009 Jan 27.

Abstract
摘要

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本文引用的文献

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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):480-5. doi: 10.1073/pnas.0811212106. Epub 2008 Dec 29.
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The autistic neuron: troubled translation?
Cell. 2008 Oct 31;135(3):401-6. doi: 10.1016/j.cell.2008.10.017.
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Autism and brain development.
Cell. 2008 Oct 31;135(3):396-400. doi: 10.1016/j.cell.2008.10.015.
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PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes.
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Why is PTEN an important tumor suppressor?
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The role of electrostatics in protein-membrane interactions.
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PTEN function: how normal cells control it and tumour cells lose it.
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