Walsh Christopher A, Morrow Eric M, Rubenstein John L R
Division of Genetics, Children's Hospital Boston, Department of Neurology and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Cell. 2008 Oct 31;135(3):396-400. doi: 10.1016/j.cell.2008.10.015.
Genetic studies are refining our understanding of neurodevelopmental mechanisms in autism. Some autism-related mutations appear to disrupt genes regulated by neuronal activity, which are especially important in development of the postnatal nervous system. Gene replacement studies in mice indicate that the developmental window to ameliorate symptoms may be wider than previously anticipated.
基因研究正在深化我们对自闭症神经发育机制的理解。一些与自闭症相关的突变似乎会破坏受神经元活动调控的基因，这些基因在出生后神经系统的发育中尤为重要。对小鼠的基因替代研究表明，改善症状的发育窗口期可能比之前预期的更宽。
