Takahashi Shinji, Tanaka Makoto
Department of Anesthesiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575.
Masui. 2009 Jan;58(1):10-5.
Several clinical and experimental studies have demonstrated gender differences in cardiovascular physiology and pharmacology. Male subjects have greater baroreflex sensitivity than female. Prolonged hypertensive reactions after adrenergic stimulation are observed in male patients. Although female subjects demonstrate low cardiac risk factors before menopause, elderly women have a higher prevalence of morbidity after coronary artery bypass surgery. In experimental articles, female sex steroids appear to exhibit immunoprotective properties following trauma and severe blood loss. Gender difference, thus, is an essential factor for tailor-made medicine. Further investigations are necessary to establish the better cardiovascular management in consideration of gender differences.
多项临床和实验研究已证明心血管生理学和药理学存在性别差异。男性受试者的压力反射敏感性高于女性。在男性患者中观察到肾上腺素能刺激后出现长时间的高血压反应。尽管女性受试者在绝经前表现出较低的心脏危险因素,但老年女性在冠状动脉搭桥手术后的发病率较高。在实验文章中,女性性激素在创伤和严重失血后似乎具有免疫保护特性。因此,性别差异是个性化医疗的一个重要因素。有必要进行进一步研究,以考虑性别差异建立更好的心血管管理方法。