Hirose T, Matsumoto I, Suzuki T
Neuroendocrinology. 1976;21(4):304-11. doi: 10.1159/000122538.
Experiments were performed on dogs with hypothalamic lesions as well as on intact and hypophysectomized dogs. Adrenal venous blood samples were collected and analyzed for 17-hydroxycorticosteroids (17-OHCS). In intact dogs, a marked increase in adrenal 17-OHCS secretion was observed after an i.v. injection of histamine and following an i.v. infusion of cyanide. Adrenal 17-OHCS secretion in response to histamine was markedly reduced but not completely abolished by hypophysectomy and was partially impaired by anterior median eminence lesions and by posterior median eminence lesions, but was not significantly impaired by supramammillary lesions. Adrenal 17-OHCS secretion in response to cyanide was completely abolished by hypophysectomy, markedly reduced by posterior median eminence lesions and partially impaired by anterior median eminence lesions and by supramammillary lesions. Thus, a partial dissociation of the adrenocortical secretory responses to histamine and cyanide was observed in dogs with hypothalamic lesions, suggesting that the mechanism and the pathway to the anterior pituitary involved in the adrenocortical secretory response to histamine and cyanide are somewhat different.
对患有下丘脑损伤的狗以及完整和垂体切除的狗进行了实验。采集肾上腺静脉血样本并分析其中的17-羟皮质类固醇（17-OHCS）。在完整的狗中，静脉注射组胺后以及静脉输注氰化物后，观察到肾上腺17-OHCS分泌显著增加。垂体切除后，对组胺反应的肾上腺17-OHCS分泌显著减少但未完全消除，前正中隆起损伤和后正中隆起损伤使其部分受损，但乳头体上区损伤未使其显著受损。垂体切除完全消除了对氰化物反应的肾上腺17-OHCS分泌，后正中隆起损伤使其显著减少，前正中隆起损伤和乳头体上区损伤使其部分受损。因此，在患有下丘脑损伤的狗中观察到肾上腺皮质对组胺和氰化物的分泌反应存在部分分离，这表明参与肾上腺皮质对组胺和氰化物分泌反应的机制以及通向垂体前叶的途径有所不同。
