Yaffe Michael B
Sci Signal. 2009 Jan 27;2(55):eg2. doi: 10.1126/scisignal.255eg2.
Despite the best policies, shared data and materials often come with so many strings attached that they are essentially unusable. Furthermore, a Catch-22 exists for academic scientists who must disclose structural data at the time of publication of the biological effects of a small molecule, because, armed with the structure, commercial entities can rapidly make and patent related molecules, thus hampering academic research. Although companies that publish original research are bound by the data- and material-sharing policies of journals, in practice they may legally restrict use and access once molecules are patented.
尽管有最好的政策，但共享的数据和材料往往附带了太多限制条件，以至于基本上无法使用。此外，对于学术科学家来说还存在一种两难困境：在发表小分子生物效应的研究成果时必须披露结构数据，因为商业实体一旦掌握了该结构，就能迅速制造相关分子并申请专利，从而阻碍学术研究。虽然发表原创研究的公司受期刊数据和材料共享政策的约束，但实际上一旦分子获得专利，它们可能会在法律上限制其使用和获取。
