Soderling Scott H
Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA.
Sci Signal. 2009 Jan 27;2(55):pe5. doi: 10.1126/scisignal.255pe5.
The seemingly simple structure of the actin filament belies the elaborate signaling pathways that regulate its assembly and disassembly in eukaryotic cells. In retrospect, this signaling complexity should not be surprising. Actin regulates many dynamic cellular processes, including protein and organelle trafficking, establishment of cell polarity, directional migration, cellular traction, and the efficiency of endocytosis. Signaling events that coordinately control actin turnover during these processes must display a high degree of sophistication. Emerging data on an important regulator of actin dynamics, the actin-related protein 2 and 3 (Arp2/3) complex, suggest a model of how this may occur.
肌动蛋白丝看似简单的结构掩盖了真核细胞中调节其组装和拆卸的复杂信号通路。回想起来,这种信号复杂性并不令人惊讶。肌动蛋白调节许多动态细胞过程,包括蛋白质和细胞器运输、细胞极性建立、定向迁移、细胞牵引力以及内吞作用效率。在这些过程中协调控制肌动蛋白周转的信号事件必须表现出高度的复杂性。关于肌动蛋白动力学的一个重要调节因子——肌动蛋白相关蛋白2和3(Arp2/3)复合体的新数据,提出了一个关于这可能如何发生的模型。