Safari Fatemeh, Suetsugu Shiro
Laboratory of Membrane and Cytoskeleton Dynamics, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Membranes (Basel). 2012 Feb 27;2(1):91-117. doi: 10.3390/membranes2010091.
Eukaryotic cells have complicated membrane systems. The outermost plasma membrane contains various substructures, such as invaginations and protrusions, which are involved in endocytosis and cell migration. Moreover, the intracellular membrane compartments, such as autophagosomes and endosomes, are essential for cellular viability. The Bin-Amphiphysin-Rvs167 (BAR) domain superfamily proteins are important players in membrane remodeling through their structurally determined membrane binding surfaces. A variety of BAR domain superfamily proteins exist, and each family member appears to be involved in the formation of certain subcellular structures or intracellular membrane compartments. Most of the BAR domain superfamily proteins contain SH3 domains, which bind to the membrane scission molecule, dynamin, as well as the actin regulatory WASP/WAVE proteins and several signal transduction molecules, providing possible links between the membrane and the cytoskeleton or other machineries. In this review, we summarize the current information about each BAR superfamily protein with an SH3 domain(s). The involvement of BAR domain superfamily proteins in various diseases is also discussed.
真核细胞具有复杂的膜系统。最外层的质膜包含各种亚结构，如内陷和突起，它们参与内吞作用和细胞迁移。此外，细胞内膜区室，如自噬体和内体，对细胞活力至关重要。Bin-双栖蛋白-Rvs167（BAR）结构域超家族蛋白通过其结构决定的膜结合表面在膜重塑中发挥重要作用。存在多种BAR结构域超家族蛋白，每个家族成员似乎都参与某些亚细胞结构或细胞内膜区室的形成。大多数BAR结构域超家族蛋白含有SH3结构域，该结构域与膜分裂分子发动蛋白、肌动蛋白调节蛋白WASP/WAVE以及几种信号转导分子结合，提供了膜与细胞骨架或其他机制之间的可能联系。在本综述中，我们总结了有关每个带有SH3结构域的BAR超家族蛋白的当前信息。还讨论了BAR结构域超家族蛋白在各种疾病中的作用。
