Pollard I, Bassett J R, Cairncross K D
Neuroendocrinology. 1976;21(4):312-30. doi: 10.1159/000122539.
A morphological and ultrastructural study is described which indicates that cellular activity in the adenohypophysis correlates well with the circulating levels of corticosterone. Intense secretory activity is observed in all tropic cells of the adenohypophysis over 10 days; thereafter the cellular morphology shows a return to the control condition. There are, however, differences in the degree of adaptation between the different tropic cells. After its initial hyperactivity, corticotrope activity returned to a control level by 20 days. Thyrotrope activity was also found to adapt to control activity, but only after 40 days. Similar patterns were observed in the stomatotrope and gonadotrope, where the initial hypertrophy returned to control levels by 20 days; thereafter, however, an inhibition was observed. The luteotrope however, seems to be an exception in that its level of activity increased throughout the duration of the stress procedure.
本文描述了一项形态学和超微结构研究，该研究表明腺垂体中的细胞活性与皮质酮的循环水平密切相关。在10天内，腺垂体的所有促激素细胞均观察到强烈的分泌活动；此后，细胞形态恢复到对照状态。然而，不同促激素细胞之间的适应程度存在差异。促肾上腺皮质激素细胞在最初的活动亢进后，到20天时活性恢复到对照水平。促甲状腺激素细胞也被发现能适应对照活性，但仅在40天后。在促生长激素细胞和促性腺激素细胞中观察到类似模式，最初的肥大在20天时恢复到对照水平；然而，此后观察到抑制现象。然而，促黄体激素细胞似乎是个例外，其活性水平在整个应激过程中都有所增加。
