Epshteĭn E V, Kozyritskiĭ V G, Bezrukov V V, Demchenko V N
Probl Endokrinol (Mosk). 1982 Mar-Apr;28(2):16-21.
The indices of some tropic adenohypophyseal functions of obese patients were compared with ultrastructural reaction of the adequate adenocytes of rats with experimental hypothalamic obesity. It was shown that in obesity significant functional and structural changes occur in adenohypophyseal cells, their extent being considerably associated with the excessive body mass. In pronounced obesity, a decrease in somato- and thyrotropic- and an increase in gonado- and corticotropic adenohypophyseal functions are seen, manifesting in ultrastructural changes of appropriate adenocytes. The results obtained allow a conclusion, that one of the mechanisms of obesity development is the changed secretory potency of adenohypophyseal cells, producing hormones, which exert a substantial influence upon lipogenesis and lipolysis processes.
将肥胖患者某些促甲状腺腺垂体功能指标与实验性下丘脑肥胖大鼠相应腺细胞的超微结构反应进行了比较。结果表明，在肥胖状态下，腺垂体细胞会发生显著的功能和结构变化，其程度与体重超标密切相关。在明显肥胖时，可见腺垂体生长激素、促甲状腺激素分泌减少，促性腺激素、促肾上腺皮质激素分泌增加，这表现为相应腺细胞的超微结构变化。所得结果表明，肥胖发生机制之一是腺垂体细胞分泌能力改变，这些细胞产生的激素对脂肪生成和脂肪分解过程有重大影响。
