Ackerman Ilana N, Dieppe Paul A, March Lyn M, Roos Ewa M, Nilsdotter Anna K, Brown Graeme C, Sloan Karen E, Osborne Richard H
The University of Melbourne, Victoria, Australia.
Arthritis Rheum. 2009 Feb 15;61(2):166-73. doi: 10.1002/art.24215.
To investigate whether variation exists in the preoperative age, pain, stiffness, and physical function of people undergoing total knee replacement (TKR) and total hip replacement (THR) at several centers in Australia and Europe.
Individual Western Ontario and McMaster Universities Osteoarthritis Index data (range 0-100, where 0 = best and 100 = worst) collected within 6 weeks prior to primary TKR and THR were extracted from 16 centers (n = 2,835) according to specified eligibility criteria. Analysis of covariance was used to evaluate differences in pain, stiffness, and physical function between centers, with adjustment for age and sex.
There was marked variation in the age of people undergoing surgery between the centers (TKR mean age 67-73 years; F[6,1004] = 4.21, P < 0.01, and THR mean age 63-72 years; F[14,1807] = 7.27, P < 0.01). Large differences in preoperative status were observed between centers, most notably for pain (TKR adjusted mean pain 52.5-61.1; F[6,1002] = 4.26, P < 0.01, and THR adjusted mean pain 49.2-65.7; F[14,1802] = 8.44, P < 0.01) and physical function (TKR adjusted mean function 52.7-61.4; F[6,1002] = 5.27, P < 0.01, and THR adjusted mean function 53.3-71.0; F[14,1802] = 6.71, P < 0.01). Large effect sizes (up to 0.98) reflect the magnitude of variation between centers and highlight the clinical relevance of these findings.
The large variations in age and preoperative status indicate substantial differences in the timing of joint replacement across the centers studied, with potential for compromised surgical outcomes due to premature or delayed surgery. Possible contributing factors include patient preferences, the absence of concrete indications for surgery, and the capacity of the health care systems.
调查在澳大利亚和欧洲的多个中心接受全膝关节置换术(TKR)和全髋关节置换术(THR)的患者术前年龄、疼痛、僵硬程度和身体功能是否存在差异。
根据特定的纳入标准,从16个中心(n = 2835)提取初次TKR和THR术前6周内收集的个体西安大略和麦克马斯特大学骨关节炎指数数据(范围0 - 100,其中0 = 最佳,100 = 最差)。采用协方差分析评估各中心之间疼痛、僵硬程度和身体功能的差异,并对年龄和性别进行校正。
各中心接受手术患者的年龄存在显著差异(TKR平均年龄67 - 73岁;F[6,1004] = 4.21,P < 0.01;THR平均年龄63 - 72岁;F[14,1807] = 7.27,P < 0.01)。各中心术前状况存在较大差异,最明显的是疼痛(TKR校正后平均疼痛52.5 - 61.1;F[6,1002] = 4.26,P < 0.01;THR校正后平均疼痛49.2 - 65.7;F[14,1802] = 8.44,P < 0.01)和身体功能(TKR校正后平均功能52.7 - 61.4;F[6,1002] = 5.2,7,P < 0.01;THR校正后平均功能53.3 - 71.0;F[14,1802] = 6.71,P < 0.01)。较大的效应量(高达0.98)反映了各中心之间差异的程度,并突出了这些发现的临床相关性。
年龄和术前状况的巨大差异表明,在所研究的各中心关节置换的时机存在实质性差异,并可能因手术过早或过晚而导致手术结果受损。可能的影响因素包括患者偏好、缺乏明确的手术指征以及医疗保健系统的能力。