Vanakara P, Dafopoulos K, Papastergiopoulou L, Kallitsaris A, Papageorgiou I, Messinis I E
Department of Obstetrics and Gynaecology, Medical School, University of Thessalia, Larissa, Greece.
Clin Endocrinol (Oxf). 2009 Jul;71(1):100-3. doi: 10.1111/j.1365-2265.2008.03456.x. Epub 2008 Oct 26.
Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge.
Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16-17 mm (Group 1) or 18-19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle-1) or atosiban (cycle-2).
Fifteen women (10 in group 1 and 5 in group 2) aged 23-35 years.
Blood samples were obtained every 6 h to characterize the midcycle LH surge.
The time interval (mean +/- SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46.8 +/- 4.8 and 45.6 +/- 9.6 h in group 1 and 6.0 +/- 2.4 and 7.5 +/- 2.8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle-2 (41.2 +/- 4.6 mIU/ml) was significantly lower than in cycle-1 (52.8 +/- 3.4 mIU/ml, P < 0.05). Nevertheless, in each group, the area under the curve for LH was similar in the two cycles.
Antagonism of endogenous OT action by atosiban does not alter the LH profile during a fully characterized midcycle LH surge, suggesting that OT is not a major regulator of LH secretion in women.
关于催产素（OT）在促黄体生成素（LH）峰期间对女性LH分泌作用的数据存在矛盾。由于在以往研究中，用于测量LH的血样采集频率较低，我们在具有完全特征性的月经周期中期LH峰的女性中重新研究了这个问题。
对正常女性进行了两个周期的研究。当优势卵泡直径达到16 - 17毫米（第1组）或18 - 19毫米（第2组）时，在第1个周期静脉输注生理盐水3小时，在第2个周期静脉输注阿托西班3小时。
15名年龄在23 - 35岁的女性（第1组10名，第2组5名）。
每6小时采集血样以表征月经周期中期LH峰。
在第1组中，从输注开始到LH峰出现的时间间隔（平均值±标准误）在两个周期分别为46.8±4.8小时和45.6±9.6小时；在第2组中分别为6.0±2.4小时和7.5±2.8小时。除了在第1组30小时这一点上，LH峰期间的LH值在两个周期相似，在该点第2个周期的LH值（41.2±4.6 mIU/ml）显著低于第1个周期（52.8±3.4 mIU/ml，P<0.05）。然而，在每组中，LH曲线下面积在两个周期相似。
阿托西班对内源性OT作用的拮抗作用不会改变具有完全特征性的月经周期中期LH峰期间的LH曲线，这表明OT不是女性LH分泌的主要调节因子。
