Hull M L, Reid R A, Evans J J, Benny P S, Aickin D R
Department of Obstetrics and Gynaecology, Christchurch School of Medicine, New Zealand.
Hum Reprod. 1995 Sep;10(9):2266-9. doi: 10.1093/oxfordjournals.humrep.a136282.
Luteinizing hormone (LH) secretion during the ovulatory cycle is believed to be predominantly regulated by gonadotrophin-releasing hormone. Investigations in animals have strongly suggested that oxytocin also participates in LH control and the physiological events controlling LH surge initiation. In the human female, however, there has been no evidence supporting oxytocin's involvement in the processes leading to ovulation. In this study the effect of a preovulatory infusion of oxytocin on the onset of the LH surge was investigated in women aged 20-35 years who had natural ovulatory menstrual cycles of lengths between 25-35 days. Vaginal ultrasound scanning monitored follicular growth during the late follicular phase. When a follicle > 14 mm in diameter was observed each woman was randomized into one of two groups. One group (n = 8) received an oxytocin infusion of 256 mIU/min for 2 h, the other group (n = 8) received normal saline. The women who were administered oxytocin at this late follicular stage had an earlier onset of the LH surge than those who had received saline (P < 0.01). The results indicate that oxytocin promotes the onset of the LH surge in humans.
促黄体生成素（LH）在排卵周期中的分泌主要被认为受促性腺激素释放激素调节。对动物的研究强烈表明，催产素也参与LH的调控以及控制LH峰起始的生理事件。然而，在人类女性中，尚无证据支持催产素参与导致排卵的过程。在本研究中，对年龄在20 - 35岁、自然排卵月经周期长度在25 - 35天之间的女性，研究了排卵前输注催产素对LH峰起始的影响。在卵泡期晚期，通过阴道超声扫描监测卵泡生长。当观察到直径>14 mm的卵泡时，将每位女性随机分为两组。一组（n = 8）接受256 mIU/min的催产素输注2小时，另一组（n = 8）接受生理盐水。在卵泡期晚期接受催产素的女性比接受生理盐水的女性LH峰起始更早（P < 0.01）。结果表明，催产素可促进人类LH峰的起始。
