Evans J J, Reid R A, Wakeman S A, Croft L B, Benny P S
Department of Obstetrics and Gynaecology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand.
Hum Reprod. 2003 Jul;18(7):1428-31. doi: 10.1093/humrep/deg291.
Regulation of the LH surge is central to the functioning of the female ovulatory cycle. In animal models, oxytocin has been shown to alter LH activity. Oxytocin advanced the LH surge and, conversely, oxytocin receptor antagonists inhibited full production of the LH surge in rats. Few data exist on the possibility that oxytocin modulates LH in women.
Ten non-pregnant women participated in this study over two menstrual cycles. One cycle was a control cycle, and the other a trial cycle; the two were separated by at least one cycle. When the diameter of an ovarian follicle was >15 mm, a subject was allocated at random into either a control or treatment group. In a control cycle, volunteers received normal saline; in a treatment cycle, volunteers received an oxytocin antagonist (atosiban).
For treatment cycles, the maximum LH concentration was significantly less than that in control cycles (42.1 +/- 6.2 versus 60.3 +/- 8.3 IU/l respectively; P < 0.05). Maximum FSH and estradiol concentrations were not significantly different between the two groups.
The results indicated that inhibition of endogenous oxytocin affects the endocrinology of the ovulatory cycle in women, and strongly suggest that oxytocin has a role in the physiological processes of LH regulation.
促黄体生成素峰的调节是女性排卵周期功能的核心。在动物模型中，已证明催产素会改变促黄体生成素的活性。催产素可使促黄体生成素峰提前出现，相反，催产素受体拮抗剂可抑制大鼠促黄体生成素峰的完全产生。关于催产素是否调节女性促黄体生成素的可能性，现有数据很少。
10名未怀孕的女性在两个月经周期内参与了本研究。一个周期为对照周期，另一个为试验周期；两者至少间隔一个周期。当卵巢卵泡直径>15 mm时，将受试者随机分为对照组或治疗组。在对照周期中，志愿者接受生理盐水；在治疗周期中，志愿者接受催产素拮抗剂（阿托西班）。
在治疗周期中，促黄体生成素的最高浓度显著低于对照周期（分别为42.1±6.2与60.3±8.3 IU/L；P<0.05）。两组之间促卵泡生成素和雌二醇的最高浓度无显著差异。
结果表明，抑制内源性催产素会影响女性排卵周期的内分泌，强烈提示催产素在促黄体生成素调节的生理过程中发挥作用。
