Lurie D M, Kent M S, Fry M M, Théon A P
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Vet Comp Oncol. 2008 Dec;6(4):257-67. doi: 10.1111/j.1476-5829.2008.00164.x.
Thirteen dogs with previously untreated multicentric lymphoma were enrolled in a prospective study investigating the effects of low-dose rate total body irradiation (TBI) and chemotherapy. Dogs received either 6 or 8 Gy TBI in half-body fractions, 2 weeks apart. Toxicity consisted of mild to moderate haematological and gastrointestinal (GI) signs. One dog died from treatment complications. Anorexia was noted independent of dose. Haematological toxicity was more common and more severe after 8 Gy treatment. GI toxicity was more likely postcaudal half-body irradiation with 8 Gy. Other than leukotrichia, late effects from radiation were not observed. Results indicated that haematological and nonhaematological toxicity was dose dependent. However, the protocol was well tolerated and treatment intensification using a 2-week inter-radiation interval was possible in all dogs treated with 6 Gy. Preliminary survival data for these dogs were very encouraging, providing a strong rationale to analyse the efficacy of low-dose rate irradiation (LDRI) in canine lymphoma.
13只先前未经治疗的多中心淋巴瘤犬被纳入一项前瞻性研究，该研究旨在调查低剂量率全身照射（TBI）和化疗的效果。犬接受了6或8 Gy的TBI，分半身照射，间隔2周。毒性表现为轻度至中度血液学和胃肠道（GI）症状。1只犬死于治疗并发症。观察到厌食与剂量无关。8 Gy治疗后血液学毒性更常见且更严重。8 Gy尾侧半身照射后更易出现胃肠道毒性。除了白毛症外，未观察到辐射的晚期效应。结果表明，血液学和非血液学毒性与剂量相关。然而，该方案耐受性良好，所有接受6 Gy治疗的犬都可以采用2周的放疗间隔进行强化治疗。这些犬的初步生存数据非常令人鼓舞，为分析低剂量率照射（LDRI）在犬淋巴瘤中的疗效提供了有力依据。
