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一个诊断难题:病例报告

A diagnostic dilemma: a case report.

作者信息

Comer David M, Edgar J David M

机构信息

Level 8 Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, N Ireland, UK.

出版信息

Cases J. 2009 Jan 29;2(1):99. doi: 10.1186/1757-1626-2-99.

DOI:10.1186/1757-1626-2-99
PMID:19178696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2640352/
Abstract

BACKGROUND

A seventy nine year old lady presented with acute bilateral foot drop and paraesthesia of her lower limbs as a presenting feature of Wegener's Granulomatosis (WG).

CASE PRESENTATION

There was no evidence of pulmonary involvement and her renal function was normal. WG can masquerade as very diverse pathology. It is recognised that neuropathy can occur early and often in the absence of more classical pulmonary and renal findings, often resulting in a delay in diagnosis.

CONCLUSION

Anti-neutrophil cytoplasmic antibody (ANCA) testing was particularly useful in this case permitting early diagnosis.

摘要

背景

一名79岁女性因韦格纳肉芽肿(WG)的表现,出现急性双侧足下垂及下肢感觉异常。

病例报告

无肺部受累证据,且其肾功能正常。WG可伪装成多种不同的病理表现。人们认识到,神经病变可早期出现,且常无更典型的肺部和肾脏表现,常导致诊断延迟。

结论

抗中性粒细胞胞浆抗体(ANCA)检测在该病例中对早期诊断尤为有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2640352/b2f25afa982b/1757-1626-2-99-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2640352/b2f25afa982b/1757-1626-2-99-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2640352/b2f25afa982b/1757-1626-2-99-1.jpg

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本文引用的文献

1
[Wegener's Granulomatosis and necrotizing ulceration of the breast. One case report].[韦格纳肉芽肿病与乳腺坏死性溃疡。1例报告]
Rev Med Interne. 2005 Feb;26(2):155-7. doi: 10.1016/j.revmed.2004.09.020.
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[Pituitary involvement in Wegener's granulomatosis. Two cases].[垂体受累于韦格纳肉芽肿病。两例报告]
Presse Med. 2004 Dec 18;33(22):1585-90. doi: 10.1016/s0755-4982(04)98998-1.
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Horner's syndrome as manifestation of Wegener's granulomatosis.霍纳综合征作为韦格纳肉芽肿病的表现
Eye (Lond). 2004 Aug;18(8):846-8. doi: 10.1038/sj.eye.6701324.
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Wegener's granulomatosis presenting as a pleural effusion.以胸腔积液为表现的韦格纳肉芽肿病。
BMJ. 2003 Jul 12;327(7406):95-6. doi: 10.1136/bmj.327.7406.95.
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Rare diseases.3: Wegener's granulomatosis.罕见疾病。3:韦格纳肉芽肿病。
Thorax. 1999 Jul;54(7):629-37. doi: 10.1136/thx.54.7.629.
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The clinical utility of ANCA positivity.抗中性粒细胞胞浆抗体(ANCA)阳性的临床应用价值。
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An audit of ANCA in routine clinical practice.常规临床实践中抗中性粒细胞胞浆抗体(ANCA)的一项审计。
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The role of antineutrophil cytoplasmic antibody (c-ANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis.
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Wegener's granulomatosis in the elderly.老年人韦格纳肉芽肿病
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