Weiner S R, Paulus H E, Weisbart R H
Arthritis Rheum. 1986 Sep;29(9):1157-9. doi: 10.1002/art.1780290915.
Wegener's granulomatosis is a systemic necrotizing granulomatous vasculitis in which the average age at onset is in the forties. The disease has an excellent response to treatment with cyclophosphamide. We proposed that the tendency to accept multisystem disease in elderly patients (greater than or equal to 60 years old) and a reluctance to administer aggressive therapy would be reflected in the diagnosis and treatment of Wegener's granulomatosis in the elderly, and that as a consequence, the delay in diagnosis and implementation of therapy could result in a needlessly higher morbidity and mortality rate for this population of patients.
韦格纳肉芽肿是一种全身性坏死性肉芽肿性血管炎，发病的平均年龄在40岁左右。该疾病对环磷酰胺治疗反应良好。我们提出，老年患者（60岁及以上）接受多系统疾病的倾向以及不愿进行积极治疗的态度，将在老年韦格纳肉芽肿的诊断和治疗中有所体现，因此，诊断和治疗的延迟可能导致该人群患者不必要地出现更高的发病率和死亡率。
