Saadi Hussein F, Nicholls M Gary, Frampton Christopher M, Benedict Sheela, Yasin Javed
Department of Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
BMC Endocr Disord. 2009 Jan 29;9:4. doi: 10.1186/1472-6823-9-4.
Vitamin D deficiency is associated with heightened risk of cardiovascular disease. Potential mechanisms include involvement of vitamin D in regulation of renin-angiotensin system and manufacture and secretion of cardiac natriuretic peptides. Our aim was to document relationships between 25 hydroxyvitamin [25(OH)D] and N-terminal pro B-type natriuretic peptide (NT-proBNP) and plasma renin activity (PRA) levels and to document the effect of vitamin D administration on NT-proBNP and PRA levels in vitamin D deficient subjects.
Serum 25(OH)D, parathyroid hormone (PTH), plasma or serum NT-proBNP and PRA levels were measured at baseline in nulliparous and lactating women and after 2 months of oral vitamin D2 (2,000 IU/day or 60,000 IU/month) supplementation to lactating women.
Baseline levels of 25(OH)D were low (<50 nmol/L) in most women whereas PRA and NT-proBNP levels were within the normal range. There were no significant correlations between baseline 25(OH)D or PTH with NT-proBNP and PRA. Vitamin D administration over a 2-month period in lactating women was associated with a decline in NT-proBNP (by 9.1 +/- 2.0 pmol/L; p < 0.001) and PRA (by 0.32 +/- 0.17 nmol/L/hr; p = 0.064). However, there were no significant correlations between the changes from baseline in 25(OH)D and either NT-proBNP (r = -0.04, p = 0.8) or PRA (r = -0.04, p = 0.8).
We found no significant correlations between 25(OH)D or PTH with NT-proBNP and PRA in vitamin D deficient women. Further information is required to clarify the effects of vitamin D administration on cardiac structure and function.
维生素D缺乏与心血管疾病风险升高有关。潜在机制包括维生素D参与肾素-血管紧张素系统的调节以及心脏利钠肽的产生和分泌。我们的目的是记录25羟维生素[25(OH)D]与N末端前B型利钠肽(NT-proBNP)及血浆肾素活性(PRA)水平之间的关系，并记录维生素D给药对维生素D缺乏受试者NT-proBNP和PRA水平的影响。
在未生育和哺乳期妇女基线时以及哺乳期妇女口服维生素D2（2000 IU/天或60000 IU/月）补充2个月后，测量血清25(OH)D、甲状旁腺激素(PTH)、血浆或血清NT-proBNP和PRA水平。
大多数女性的基线25(OH)D水平较低(<50 nmol/L)，而PRA和NT-proBNP水平在正常范围内。基线25(OH)D或PTH与NT-proBNP和PRA之间无显著相关性。哺乳期妇女在2个月内给予维生素D与NT-proBNP下降（9.1±2.0 pmol/L；p<0.001）和PRA下降（0.32±0.17 nmol/L/hr；p = 0.064）相关。然而，25(OH)D相对于基线的变化与NT-proBNP（r = -0.04，p = 0.8）或PRA（r = -0.04，p = 0.8）之间均无显著相关性。
我们发现维生素D缺乏女性中25(OH)D或PTH与NT-proBNP和PRA之间无显著相关性。需要更多信息来阐明维生素D给药对心脏结构和功能的影响。
