伪菌素A及其类似物作为免疫球蛋白E[免疫球蛋白E的校正]产生的抑制剂。
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
作者信息
Ishikawa Minoru, Ninomiya Tomohisa, Akabane Hirotomo, Kushida Nobuaki, Tsujiuchi Go, Ohyama Makoto, Gomi Shuichi, Shito Keiko, Murata Takashi
机构信息
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan.
出版信息
Bioorg Med Chem Lett. 2009 Mar 1;19(5):1457-60. doi: 10.1016/j.bmcl.2009.01.029. Epub 2009 Jan 15.
A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.
天然产物pseurotin A在体外可抑制IgE的产生。对pseurotin A进行了多种化学修饰。pseurotin类似物的构效关系研究表明，10-脱氧pseurotin A强烈抑制IgE的产生，IC(50)为0.066微摩尔。还发现了另一种天然产物synerazol的免疫抑制活性。
Zotero 插件