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来自珊瑚共生真菌的次生代谢产物：来源、化学性质及生物活性

Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities.

作者信息

Chen Ying, Pang Xiaoyan, He Yanchun, Lin Xiuping, Zhou Xuefeng, Liu Yonghong, Yang Bin

机构信息

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.

出版信息

J Fungi (Basel). 2022 Oct 3;8(10):1043. doi: 10.3390/jof8101043.

DOI:10.3390/jof8101043
PMID:36294608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9604832/
Abstract

Our study of the secondary metabolites of coral-associated fungi produced a valuable and extra-large chemical database. Many of them exhibit strong biological activity and can be used for promising drug lead compounds. Serving as an epitome of the most promising compounds, which take the ultra-new skeletons and/or remarkable bioactivities, this review presents an overview of new compounds and bioactive compounds isolated from coral-associated fungi, covering the literature from 2010 to 2021. Its scope included 423 metabolites, focusing on the bioactivity and structure diversity of these compounds. According to structure, these compounds can be roughly classified as terpenes, alkaloids, peptides, aromatics, lactones, steroids, and other compounds. Some of them described in this review possess a wide range of bioactivities, such as anticancer, antimicrobial, antifouling, and other activities. This review aims to provide some significant chemical and/or biological enlightenment for the study of marine natural products and marine drug development in the future.

摘要

我们对与珊瑚相关真菌的次生代谢产物的研究产生了一个有价值的超大型化学数据库。其中许多化合物具有很强的生物活性，可用于开发有前景的药物先导化合物。作为最具前景化合物的缩影，这些化合物具有全新的骨架和/或显著的生物活性，本综述概述了从2010年到2021年从与珊瑚相关真菌中分离出的新化合物和生物活性化合物。其范围包括423种代谢产物，重点关注这些化合物的生物活性和结构多样性。根据结构，这些化合物可大致分为萜类、生物碱、肽类、芳香族化合物、内酯、甾体及其他化合物。本综述中描述的一些化合物具有广泛的生物活性，如抗癌、抗菌、防污等活性。本综述旨在为未来海洋天然产物研究和海洋药物开发提供一些重要的化学和/或生物学启示。

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