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1
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP".现在双方观点：ATP与泛连接蛋白1半通道的多种相互作用。聚焦于“一种渗透物调节其渗透孔：ATP对泛连接蛋白1通道的抑制作用”。
Am J Physiol Cell Physiol. 2009 Feb;296(2):C235-41. doi: 10.1152/ajpcell.00639.2008.
2
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.一种调节其渗透孔的通透剂：ATP对泛连接蛋白1通道的抑制作用
Am J Physiol Cell Physiol. 2009 Feb;296(2):C250-5. doi: 10.1152/ajpcell.00433.2008. Epub 2008 Oct 22.
3
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.P2X7受体-泛连接蛋白1复合物：药理学与信号传导
Am J Physiol Cell Physiol. 2008 Sep;295(3):C752-60. doi: 10.1152/ajpcell.00228.2008. Epub 2008 Jul 2.
4
Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death.在ATP诱导的小鼠T细胞死亡过程中，泛连接蛋白1通道在P2X7受体的下游发挥作用。
Channels (Austin). 2014;8(2):142-56. doi: 10.4161/chan.28122. Epub 2014 Mar 3.
5
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium.ATP通过P2Y受体以及胞质钙激活泛连接蛋白1通道。
FEBS Lett. 2006 Jan 9;580(1):239-44. doi: 10.1016/j.febslet.2005.12.004. Epub 2005 Dec 12.
6
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X receptors.三磷酸腺苷通过连接蛋白 1 通道和 P2X 受体的活性促进树突状细胞的快速迁移。
Sci Signal. 2017 Nov 21;10(506):eaah7107. doi: 10.1126/scisignal.aah7107.
7
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.泛连接蛋白-1通过ATP门控的P2X7受体介导大孔形成和白细胞介素-1β释放。
EMBO J. 2006 Nov 1;25(21):5071-82. doi: 10.1038/sj.emboj.7601378. Epub 2006 Oct 12.
8
The participation of plasma membrane hemichannels to purinergic signaling.质膜半通道在嘌呤能信号传导中的作用。
Biochim Biophys Acta. 2013 Jan;1828(1):79-93. doi: 10.1016/j.bbamem.2012.01.002. Epub 2012 Jan 12.
9
Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning.缝隙连接蛋白-I/P2X7 嘌呤能受体通道介导缺血预处理和后处理诱导的心脏保护剂释放。
J Cardiovasc Pharmacol Ther. 2010 Jun;15(2):190-5. doi: 10.1177/1074248409360356. Epub 2010 Mar 3.
10
Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage.P2X7受体或泛连接蛋白1通道的阻断同样可减轻缺血后损伤。
J Cereb Blood Flow Metab. 2015 May;35(5):843-50. doi: 10.1038/jcbfm.2014.262. Epub 2015 Jan 21.

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1
Pannexins in the musculoskeletal system: new targets for development and disease progression.骨骼肌系统中的 Pannexin：开发和疾病进展的新靶点。
Bone Res. 2024 May 6;12(1):26. doi: 10.1038/s41413-024-00334-8.
2
Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke.Pannexin1 通道介导热缺血性脑卒中的炎症反应。
Aging Dis. 2024 May 7;15(3):1296-1307. doi: 10.14336/AD.2023.0303.
3
Possible role of pannexin 1 channels and purinergic receptors in the pathogenesis and mechanism of action of SARS-CoV-2 and therapeutic potential of targeting them in COVID-19.缝隙连接蛋白 1 通道和嘌呤能受体在 SARS-CoV-2 发病机制和作用机制中的可能作用，以及针对它们在 COVID-19 中的治疗潜力。
Life Sci. 2022 May 15;297:120482. doi: 10.1016/j.lfs.2022.120482. Epub 2022 Mar 11.
4
Human Pannexin 1 channel: Insight in structure-function mechanism and its potential physiological roles.人类连接蛋白 1 通道：结构-功能机制的深入了解及其潜在的生理作用。
Mol Cell Biochem. 2021 Mar;476(3):1529-1540. doi: 10.1007/s11010-020-04002-3. Epub 2021 Jan 4.
5
Astroglial Ca-Dependent Hyperexcitability Requires P2Y Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy.在慢性癫痫模型中，星形胶质细胞钙依赖性过度兴奋需要P2Y嘌呤能受体和泛连接蛋白-1通道激活。
Front Cell Neurosci. 2018 Nov 23;12:446. doi: 10.3389/fncel.2018.00446. eCollection 2018.
6
Neuroimmune Communication in Health and Disease.神经免疫通讯在健康与疾病中的作用
Physiol Rev. 2018 Oct 1;98(4):2287-2316. doi: 10.1152/physrev.00035.2017.
7
Purines and Carotid Body: New Roles in Pathological Conditions.嘌呤与颈动脉体：病理状态下的新作用。
Front Pharmacol. 2017 Dec 12;8:913. doi: 10.3389/fphar.2017.00913. eCollection 2017.
8
Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics.电流门控/幅度依赖性单通道门控动力学的小鼠连接蛋白 1 通道：门控动力学的新概念。
Sci Rep. 2017 Sep 5;7(1):10512. doi: 10.1038/s41598-017-10921-x.
9
An autocrine ATP release mechanism regulates basal ciliary activity in airway epithelium.一种自分泌ATP释放机制调节气道上皮细胞的基础纤毛活动。
J Physiol. 2017 Jul 15;595(14):4755-4767. doi: 10.1113/JP273996. Epub 2017 Jun 15.
10
Wound-induced Ca wave propagates through a simple release and diffusion mechanism.伤口诱导的钙波通过简单的释放和扩散机制传播。
Mol Biol Cell. 2017 Jun 1;28(11):1457-1466. doi: 10.1091/mbc.E16-10-0695. Epub 2017 Apr 12.

本文引用的文献

1
Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.泛素连接蛋白-1半通道的激活增强了海马体中的异常爆发活动。
Science. 2008 Dec 5;322(5907):1555-9. doi: 10.1126/science.1165209.
2
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear.通过连接蛋白半通道释放ATP以及第二信使的间隙连接传递，可使Ca2+信号在内耳中传播。
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18770-5. doi: 10.1073/pnas.0800793105. Epub 2008 Dec 1.
3
Voltage dependence of ATP secretion in mammalian taste cells.哺乳动物味觉细胞中ATP分泌的电压依赖性
J Gen Physiol. 2008 Dec;132(6):731-44. doi: 10.1085/jgp.200810108.
4
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.在哺乳动物细胞中表达的泛连接蛋白-1电流的药理学特性
J Pharmacol Exp Ther. 2009 Feb;328(2):409-18. doi: 10.1124/jpet.108.146365. Epub 2008 Nov 20.
5
P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis.心肌细胞中的P2Y6受体-Gα12/13信号传导引发压力超负荷诱导的心脏纤维化。
EMBO J. 2008 Dec 3;27(23):3104-15. doi: 10.1038/emboj.2008.237. Epub 2008 Nov 13.
6
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.一种调节其渗透孔的通透剂：ATP对泛连接蛋白1通道的抑制作用
Am J Physiol Cell Physiol. 2009 Feb;296(2):C250-5. doi: 10.1152/ajpcell.00433.2008. Epub 2008 Oct 22.
7
Connexin and pannexin hemichannels of neurons and astrocytes.神经元和星形胶质细胞的连接蛋白和孔蛋白半通道。
Channels (Austin). 2008 Mar-Apr;2(2):81-6. doi: 10.4161/chan.2.2.6003. Epub 2008 Mar 29.
8
Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels.通过泛连接蛋白-1半通道释放的ATP对T细胞活化的嘌呤能调控。
Sci Signal. 2008 Sep 30;1(39):ra6. doi: 10.1126/scisignal.1160583.
9
Currently used methods for identification and characterization of hemichannels.目前用于半通道识别和表征的方法。
Cell Commun Adhes. 2008 May;15(1):207-18. doi: 10.1080/15419060802014198.
10
Diverse subcellular distribution profiles of pannexin 1 and pannexin 3.泛连接蛋白1和泛连接蛋白3的多种亚细胞分布模式。
Cell Commun Adhes. 2008 May;15(1):133-42. doi: 10.1080/15419060802014115.

Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP".

作者信息

Dubyak George R

出版信息

Am J Physiol Cell Physiol. 2009 Feb;296(2):C235-41. doi: 10.1152/ajpcell.00639.2008.

DOI:10.1152/ajpcell.00639.2008
PMID:19179656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2643857/
Abstract
摘要