主动脉脉搏波速度可预测日本中老年男性的心血管死亡率。
Aortic pulse wave velocity predicts cardiovascular mortality in middle-aged and elderly Japanese men.
作者信息
Inoue Noriko, Maeda Ryo, Kawakami Hideshi, Shokawa Tomoki, Yamamoto Hideya, Ito Chikako, Sasaki Hideo
机构信息
Hiroshima City Medical Association Clinical Laboratory Center, 3-8-6 Senda-machi, Naka-ku, Hiroshima 730-8611, Japan.
出版信息
Circ J. 2009 Mar;73(3):549-53. doi: 10.1253/circj.cj-08-0492. Epub 2009 Jan 30.
BACKGROUND
Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design.
METHODS AND RESULTS
From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s).
CONCLUSIONS
An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
背景
主动脉脉搏波速度（PWV）被广泛用作动脉僵硬度的无创指标，在本研究中用于采用纵向研究设计调查日本中老年人群中PWV与心血管死亡率之间的关系。
方法与结果
1988年至2003年，共招募了3960名男性（基线时年龄为50 - 69岁），他们接受了体检和PWV测量（该测量针对舒张压进行了标准化），并根据PWV值分为4组。平均随访期为8.2年。在整个随访期内，全因死亡率和心血管疾病死亡率均随PWV升高而显著增加。与最低四分位数（<7.5 m/s）相比，PWV最高四分位数（>9.0 m/s）的全因和心血管疾病死亡率的多变量调整相对风险分别为1.28（95%置信区间（CI）0.97 - 1.68）和1.83（95%CI 1.02 - 3.29）。
结论
PWV升高可预测日本中老年男性的心血管死亡率。
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