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从细胞治疗的基础到应用:攻克神经退行性疾病的垫脚石——会议报告

From the basics to application of cell therapy, a steppingstone to the conquest of neurodegeneration: a meeting report.

作者信息

Park Dong-Hyuk, Eve David J, Borlongan Cesario V, Klasko Stephen K, Cruz L Eduardo, Sanberg Paul R

机构信息

Center of Excellence for Aging and Brain Repair, Dept. Neurosurgery, Tampa, FL, USA.

出版信息

Med Sci Monit. 2009 Feb;15(2):RA23-31.

Abstract

The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) showcases the latest research trends in neurodegenerative disease and the related medical regenerative science. The 2008 ASNTR meeting covered a variety of different topics ranging from basic research to exploration of currently unknown pathogenesis and mechanisms for specific neurodegenerative disease such as Parkinson's disease, Alzheimer's disease, or stroke. This included studies to characterize stem cells, such as neural stem cells, embryonic stem cells, bone marrow mesenchymal stem cells, and human umbilical cord blood cells, for transplantation and the conditions necessary to maximize the efficacy of endogenous and exogenous stem cells, such as isolation, purification, differentiation, and migration. Moreover, a number of studies looked at methods for more advanced application of transplantation of cells or specific factors, through tissue engineering or manipulation beyond simple injection. Finally, well-known or previously un-known dietary supplementation or pharmacological materials that can affect the nervous system positively or negatively, were also important topics.

摘要

美国神经治疗与修复学会(ASNTR)年会展示了神经退行性疾病及相关医学再生科学的最新研究趋势。2008年ASNTR会议涵盖了各种不同主题,从基础研究到对特定神经退行性疾病(如帕金森病、阿尔茨海默病或中风)目前未知的发病机制和病因的探索。这包括对用于移植的干细胞(如神经干细胞、胚胎干细胞、骨髓间充质干细胞和人脐带血细胞)进行特性研究,以及使内源性和外源性干细胞功效最大化所需的条件,如分离、纯化、分化和迁移。此外,一些研究着眼于通过组织工程或超越简单注射的操作,更先进地应用细胞或特定因子移植的方法。最后,能对神经系统产生积极或消极影响的知名或此前未知的膳食补充剂或药理物质,也是重要的主题。

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