Park Dong-Hyuk, Borlongan Cesario V, Eve David J, Sanberg Paul R
Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, Tampa, FL 33612, USA.
Med Sci Monit. 2008 Nov;14(11):RA206-20.
New scientific technologies and concepts have led to the revolution of the field of regenerative medicine, as highlighted in our review of articles published in the journal Cell Transplantation - The Regenerative Medicine Journal over the last two years. From 2006 to 2007, 373 articles were published; a remarkable increase over the last two time periods (2004-2005 and 2005-2006), partly due to inclusion of American Society for Neural Therapy and Repair (ASNTR) meeting abstracts in the current analysis. The neuroscience section has increased immensely in the number of articles and percentage of all manuscripts. The tissue engineering and bioartificial organs section is now equally important with the islets and other endocrines section. There is a considerable increase in the proportion of manuscripts related to transplants with stem cells, progenitors, and bone marrow and nontransplants. Stem cell transplants can be ranked in the following descending order of preference; bone marrow-derived cells, neural stem cells, human umbilical cord blood cells, embryonic stem cells, and myoblasts. Bone marrow derived cells and human umbilical cord blood cell have been used for various disease fields. The non-stem cell transplantation group is made up primarily of islet cells, followed by biomaterials, and other cells or tissues from a variety of sources. The field of regenerative medicine as represented by the journal Cell Transplantation is not restricted solely to transplantation. The majority of the non-transplantation-based articles relate to methods other than transplant for treatment, e.g. dietary supplementation, preparation for transplantation (isolation, differentiation and growth of cells or tissues), and pathology (e.g. neurodegenerative diseases such as Parkinson's disease).
新的科学技术和概念引发了再生医学领域的革命，正如我们对过去两年发表在《细胞移植——再生医学杂志》上的文章进行综述时所强调的那样。2006年至2007年，共发表了373篇文章；与前两个时期（2004 - 2005年和2005 - 2006年）相比有显著增加，部分原因是本次分析纳入了美国神经治疗与修复学会（ASNTR）会议摘要。神经科学部分的文章数量和在所有稿件中所占的百分比都有大幅增加。组织工程和生物人工器官部分现在与胰岛及其他内分泌部分同样重要。与干细胞、祖细胞、骨髓移植以及非移植相关的稿件比例有相当大的增加。干细胞移植按优先顺序可排列如下：骨髓来源的细胞、神经干细胞、人脐带血细胞、胚胎干细胞和成肌细胞。骨髓来源的细胞和人脐带血细胞已被用于各种疾病领域。非干细胞移植组主要由胰岛细胞组成，其次是生物材料以及来自各种来源的其他细胞或组织。以《细胞移植》杂志为代表的再生医学领域并不局限于移植。大多数非基于移植的文章涉及除移植之外的治疗方法，例如膳食补充、移植准备（细胞或组织的分离、分化和生长）以及病理学（如帕金森病等神经退行性疾病）。
