[钴胺素辅酶对大鼠几种可移植肿瘤生长及延长接种Zajdel腹水瘤大鼠寿命的影响]
[Effect of cobamide coenzyme on the growth of several transplantable tumors in rats and on prolonging the life of rats with grafted Zajdel ascitic tumor].
作者信息
Brazhenas G R, Kanopkaĭte S I, Alenene A I, Narbutene G L, Bartkiavichene V V
出版信息
Prikl Biokhim Mikrobiol. 1976 Nov-Dec;12(6):819-24.
The effect of the cobamide coenzyme (5,6-dimethylbenzimidazolyl-Co-5'-deoxyadenozylcobamide, DBC) on the growth of some forms of rat tumours and on the prolongation of survival of rats with implanted Zajdela ascites hepatoma was compared with that of cyanocobalamine (5,6-dimethylbenzimidazolyl-Co-cyanocobamide, CN-B12). The effect of DBC was shown to differ from that of CN-B12. DBC did not stimulate the growth of the investigated forms of tumours and prolonged survival of rats with implanted Zajdela ascites hepatoma. The rats displayed cancer resistance when DBC or CN-B12 were injected before implantation of tumours or Zajdela ascites hepatoma.
将钴胺素辅酶（5,6 - 二甲基苯并咪唑基 - Co - 5'-脱氧腺苷钴胺素，DBC）对大鼠某些肿瘤生长的影响以及对植入扎伊德拉腹水肝癌大鼠生存期延长的影响，与氰钴胺素（5,6 - 二甲基苯并咪唑基 - Co - 氰钴胺素，CN - B12）进行了比较。结果表明，DBC的作用与CN - B12不同。DBC不会刺激所研究的肿瘤生长形式，却能延长植入扎伊德拉腹水肝癌大鼠的生存期。当在肿瘤或扎伊德拉腹水肝癌植入前注射DBC或CN - B12时，大鼠表现出抗癌能力。
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