[Effect of cyanocobalamin, cobamide coenzyme and the cytostatic hispen on changes in cobalamin levels in healthy rats and rats with transplanted sarcoma M-1].

The influence of cyanocobalamine (CN-B12), cobamide coenzyme (5'-deoxyadenosyl-B12, DBC) and the cytostatic hisphen on the level of cobalamines in the blood serum, liver, kidney, heart and in the tumor of healthy and sarcoma M-1 implanted rats was studied. In the above organs and tissues cobalamines were found to occur in the free and protein-bound state (cobalamine-protein complexes). The complexes were of different stability. The ratio of free to protein-bound cobalamines varied. The content of cobalamine-protein complexes in healthy and tumorous tissues was different. CN-B12, DBC and hisphen influenced specifically the redistribution of cobalamine and protein-bound complexes.