结核分枝杆菌H37Rv的Rv1712基因座编码一种功能性CMP激酶，该激酶优先磷酸化dCMP。
The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
作者信息
Thum Caroline, Schneider Cristopher Z, Palma Mario S, Santos Diógenes S, Basso Luiz A
机构信息
Av. Ipiranga 6681, Tecnopuc-Prédio 92A, Porto Alegre, RS 90619-900, Brazil.
出版信息
J Bacteriol. 2009 Apr;191(8):2884-7. doi: 10.1128/JB.01337-08. Epub 2009 Jan 30.
Abstract
The Mycobacterium tuberculosis cmk gene, predicted to encode a CMP kinase (CMK), was cloned and expressed, and its product was purified to homogeneity. Steady-state kinetics confirmed that M. tuberculosis CMK is a monomer that preferentially phosphorylates CMP and dCMP by a sequential mechanism. A plausible role for CMK is discussed.
摘要
结核分枝杆菌的cmk基因，预计编码一种CMP激酶（CMK），被克隆并表达，其产物被纯化至同质。稳态动力学证实，结核分枝杆菌CMK是一种单体，通过顺序机制优先磷酸化CMP和dCMP。文中讨论了CMK可能的作用。
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