Gainer R B
West Virginia University, Morgantown.
Hosp Pract (Off Ed). 1991 Sep;26 Suppl 5:24-30; discussion 55-7. doi: 10.1080/21548331.1991.11707740.
Ceftriaxone is generally recognized to be safe and effective when administered either intravenously or intramuscularly to both adults and children as a single drug for skin and skin structure infections. An advantage of ceftriaxone over the other third-generation cephalosporins is its long serum half-life, which allows it to be given every 12 hours in children and every 24 hours in most adults. There is no question that ceftriaxone is effective for skin and soft tissue infections, particularly those caused by staphylococci and streptococci. The drug's sales to home infusion companies around the country attest to its widespread use for such infections. The fact remains, however, that the data required to substantiate efficacy and safety for ceftriaxone or for any of the other third-generation cephalosporins are just not available in large numbers.
头孢曲松通常被认为，当作为单一药物用于皮肤和皮肤结构感染，对成人和儿童进行静脉或肌肉注射给药时，是安全有效的。头孢曲松相对于其他第三代头孢菌素的一个优势是其较长的血清半衰期，这使得它在儿童中每12小时给药一次，在大多数成人中每24小时给药一次。毫无疑问，头孢曲松对皮肤和软组织感染有效，尤其是由葡萄球菌和链球菌引起的感染。该药物在全国范围内向家庭输液公司的销售证明了其在此类感染中的广泛应用。然而，事实仍然是，大量证实头孢曲松或任何其他第三代头孢菌素疗效和安全性所需的数据并不存在。
