Parish L C, Witkowski J A, Snow R, Eron L, Mogabgab W J
Int J Dermatol. 1986 May;25(4):258-65. doi: 10.1111/j.1365-4362.1986.tb02239.x.
The safety and efficacy of ceftazidime administered as 0.5 g every 8 hours (q8h) or 1.0 g q8h for at least 5 days were compared in 197 patients and found to be effective in the treatment of cellulitis, abscesses, skin ulcers, and wound infections. Staphylococcus aureus was the predominant pathogen in both treatment groups with approximately half of the isolates from each treatment group being gram-positive. Pseudomonas aeruginosa was the most common gram-negative isolate. P. aeruginosa, Proteus mirabilis, and Escherichia coli each comprised 5-12% of the isolates from each treatment group. Clinical cure or improvement was achieved in 98.7% of the patients in each treatment group. Concurrently with clinically successful treatment, a high rate of bacteriologic eradication without superinfection was achieved with the 0.5-g regimen (84% of all isolates) and the 1.0-g regimen (92%).
在197例患者中比较了每8小时（q8h）给予0.5克或每8小时给予1.0克头孢他啶至少5天的安全性和有效性，发现其对治疗蜂窝织炎、脓肿、皮肤溃疡和伤口感染有效。金黄色葡萄球菌是两个治疗组中的主要病原体，每个治疗组中约一半的分离株为革兰氏阳性菌。铜绿假单胞菌是最常见的革兰氏阴性分离株。铜绿假单胞菌、奇异变形杆菌和大肠杆菌在每个治疗组的分离株中各占5%-12%。每个治疗组中98.7%的患者实现了临床治愈或改善。在临床治疗成功的同时，0.5克治疗方案（所有分离株的84%）和1.0克治疗方案（92%）实现了高比例的细菌清除且无二重感染。
