Davis Mellar P, Yavuzsen Tugba, Khoshknabi Dilara, Kirkova Jordanka, Walsh Declan, Lasheen Wael, Lagman Ruth, Karafa Matthew T
Harry R. Horvitz Center for Palliative Medicine, Taussig Cancer Center, Cleveland Clinic, Ohio 44195, USA.
Am J Hosp Palliat Care. 2009 Jun-Jul;26(3):180-7. doi: 10.1177/1049909108330028. Epub 2009 Jan 30.
We wished to determine bioelectrical impedance (BIA) correlates before hydration or changes during hydration and determine if these changes were prognostically important.
Fifty eligible patients underwent BIA measurements 3 consecutive days. Laboratory studies (electrolytes, creatinine, and hemoglobin) on day 1; weights and vital signs were recorded. Kaplan-Meier survival estimates were made at 30 and 60 days. Hazard ratios (HRs) based on Cox proportional hazards model were calculated.
Weight loss was associated with shorter survival. A higher phase angle (PA) on day 1 predicted longer survival. Increased PA during hydration predicted shorter survival: increased weight during hydration predicted longer survival.
Higher phase angle before hydration predicts poorer survival and, paradoxically, an increase in phase angle during hydration predicted poorer survival and preexisting intracellular dehydration, cachexia, or poor membrane function.
Phase angle and weight during hydration predict survival in cancer.
我们希望确定水化前生物电阻抗（BIA）的相关因素或水化过程中的变化，并确定这些变化在预后方面是否重要。
50名符合条件的患者连续3天进行BIA测量。在第1天进行实验室检查（电解质、肌酐和血红蛋白）；记录体重和生命体征。在30天和60天时进行Kaplan-Meier生存估计。基于Cox比例风险模型计算风险比（HRs）。
体重减轻与较短的生存期相关。第1天较高的相位角（PA）预示着较长的生存期。水化过程中PA增加预示着较短的生存期；水化过程中体重增加预示着较长的生存期。
水化前较高的相位角预示着较差的生存期，矛盾的是，水化过程中相位角增加预示着较差的生存期以及先前存在的细胞内脱水、恶病质或膜功能不良。
水化过程中的相位角和体重可预测癌症患者的生存期。
Zotero 插件