Kakigi R, Shibasaki H
Department of Internal Medicine, Saga Medical School, Japan.
J Clin Neurophysiol. 1991 Jul;8(3):320-30. doi: 10.1097/00004691-199107010-00008.
This is the first study to evaluate the effects of age, gender, and stimulus side on scalp topography of somatosensory evoked potentials (SEPs) following stimulation of the median nerve by using computerized bit-mapped color images. Seventy-four normal subjects whose ages ranged from 7 to 88 years were studied, and Student's t test was performed on averaged mean maps and their standard deviations of each recognizable component by using the significance probability mapping method. Topographic maps of most components in aged subjects were significantly different from those in young subjects, mainly because of higher amplitudes of the components in the aged group. This difference was particularly significant for later components with the peak latencies of longer than 40 ms. Gender and stimulus side caused no significant differences in amplitude and topography of the components. Therefore, for clinical application of topographic maps of median nerve SEPs, a difference of gender and stimulus side could be disregarded, but it is necessary to consider the age effect.
这是第一项使用计算机位图彩色图像评估年龄、性别和刺激侧对正中神经刺激后体感诱发电位（SEP）头皮地形图影响的研究。研究了74名年龄在7至88岁之间的正常受试者，并使用显著性概率映射方法对每个可识别成分的平均均值图及其标准差进行了Student's t检验。老年受试者大多数成分的地形图与年轻受试者的显著不同，主要是因为老年组成分的波幅更高。这种差异对于峰值潜伏期超过40毫秒的后期成分尤为显著。性别和刺激侧在成分的波幅和地形图上未引起显著差异。因此，对于正中神经SEP地形图的临床应用，可以忽略性别和刺激侧的差异，但有必要考虑年龄效应。
