Shepherd N A
Department of Histopathology, Gloucestershire Royal Hospital.
J Clin Pathol. 1991 Sep;44(9):726-33. doi: 10.1136/jcp.44.9.726.
When all of the macroscopic and microscopic features of Crohn's disease and ulcerative colitis are present, the correct diagnosis is usually made without difficulty. When some of the changes are absent, the accuracy of diagnosis is reduced. This review has outlined those diseases which feature some of these pathological changes and may masquerade as idiopathic chronic inflammatory bowel disease. Some of the pathological mimics are iatrogenic while other common diseases, such as bacterial infection, ischaemia, and diverticulosis may produce confusing histological appearances. The picture is complicated by the fact that many of these pathological imitators may themselves cause or predispose to chronic inflammatory bowel disease, or may complicate chronic inflammatory bowel disease. For example, drugs and infectious agents are recognisable causes of relapse in ulcerative colitis; Crohn's disease may cause diverticulitis in patients with diverticulosis; and lymphoma may complicate ulcerative colitis. It behooves all practising histopathologists to recognise these mimics of ulcerative colitis and Crohn's disease to ensure appropriate management for patients with inflammatory pathology of the intestines.
当克罗恩病和溃疡性结肠炎的所有宏观和微观特征都存在时，通常不难做出正确诊断。当某些改变不存在时，诊断的准确性会降低。本综述概述了那些具有这些病理变化中的一些特征且可能伪装成特发性慢性炎症性肠病的疾病。一些病理模拟情况是医源性的，而其他常见疾病，如细菌感染、缺血和憩室病，可能会产生令人困惑的组织学表现。由于许多这些病理模仿者本身可能会导致或易患慢性炎症性肠病，或者可能使慢性炎症性肠病复杂化，情况变得更加复杂。例如，药物和感染因子是溃疡性结肠炎复发的可识别原因；克罗恩病可能会在患有憩室病的患者中引发憩室炎；淋巴瘤可能会使溃疡性结肠炎复杂化。所有执业组织病理学家都有必要认识到这些溃疡性结肠炎和克罗恩病的模仿者，以确保对患有肠道炎症性病变的患者进行适当的管理。
