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腹腔镜辅助下克罗恩病原发性回结肠切除术的安全性、可行性及短期疗效

Safety, feasibility, and short-term outcomes of laparoscopically assisted primary ileocolic resection for Crohn's disease.

作者信息

Soop Mattias, Larson David W, Malireddy Kishore, Cima Robert R, Young-Fadok Tonia M, Dozois Eric J

机构信息

Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

出版信息

Surg Endosc. 2009 Aug;23(8):1876-81. doi: 10.1007/s00464-008-0308-z. Epub 2009 Jan 28.

Abstract

BACKGROUND

Outcomes of laparoscopic resection for ileocecal Crohn's disease have been reported previously in smaller studies, suggesting its short-term advantages over open surgery. This study assessed the safety and recovery parameters in the largest, consecutive, single-institution series to date.

METHODS

Consecutive patients undergoing laparoscopically assisted primary ileocolic resection for Crohn's disease between 1994 and 2006 were identified in an institutional prospectively collected database. Operative and postoperative outcomes at 30 days were studied.

RESULTS

In this study, 109 patients (35 men) with a mean age of 35 +/- 14 years and a mean body mass index (BMI) of 25 +/- 6 kg/m(2) were identified. The main indications for surgery were medically refractory disease (63%) and fibrous stenosis (27%). In 41% of the cases, previous abdominal surgery had been performed. The surgery had a mean duration of 150 +/- 45 min and a conversion rate of 6%. The overall 30-day morbidity rate was 11%, and the reoperation rate was 1%. The mortality rate was 0%. The median postoperative hospital stay was 4 days (range, 2-15 days).

CONCLUSIONS

This series, the largest reported to date, concurs with recent metaanalyses findings that laparoscopically assisted primary ileocecal resection for Crohn's disease is safe and feasible, resulting in better short-terms outcomes than open resection. This operation is therefore the procedure of choice for Crohn's disease at our institutions.

摘要

背景

此前在一些规模较小的研究中报告了腹腔镜切除治疗回盲部克罗恩病的结果,提示其相对于开放手术具有短期优势。本研究在迄今最大的、连续的、单机构系列研究中评估了安全性和恢复参数。

方法

在一个机构前瞻性收集的数据库中确定1994年至2006年间接受腹腔镜辅助原发性回结肠切除术治疗克罗恩病的连续患者。研究了30天的手术和术后结果。

结果

本研究纳入了109例患者(35例男性),平均年龄35±14岁,平均体重指数(BMI)为25±6kg/m²。手术的主要指征是内科治疗无效的疾病(63%)和纤维性狭窄(27%)。41%的病例曾接受过腹部手术。手术平均持续时间为150±45分钟,中转率为6%。30天总体发病率为11%,再次手术率为1%。死亡率为0%。术后中位住院时间为4天(范围2 - 15天)。

结论

本系列研究是迄今报告的最大规模研究,与最近的荟萃分析结果一致,即腹腔镜辅助原发性回结肠切除术治疗克罗恩病是安全可行的,短期结果优于开放切除术。因此,该手术是我们机构治疗克罗恩病的首选术式。

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