Miettinen T A, Hallikainen M, Raitakari O T, Viikari J, Gylling H
Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, room C4 22, P.O. Box 700, FIN-00029 HUS, Finland.
Nutr Metab Cardiovasc Dis. 2009 Oct;19(8):525-31. doi: 10.1016/j.numecd.2008.10.009. Epub 2009 Jan 29.
To show tracking of cholesterol metabolism, the ratios to cholesterol of e.g. serum cholestenol, desmosterol, and lathosterol, reflecting cholesterol synthesis, and cholestanol, campesterol, avenasterol and sitosterol, reflecting cholesterol absorption, were measured 21 years apart.
In random population samples initially comprising 12- (n=162), 15- (n=158), and 18-year-old (n=148) males participating in the Cardiovascular Risk in Young Finns Study, serum sterols and squalene were measured with gas-liquid chromatography in 1980 and 2001. Quartiles of cholestanol, indicating low to high cholesterol absorption, were defined from the cholestanol values in 1980. Serum cholesterol increased in the oldest age group only, but synthesis markers (except desmosterol) increased in all age groups after the follow-up (e.g. lathosterol, total population +47.3+/-2.6% (SE), P<0.001). Campesterol (+69.0+/-3.0%, P<0.001) and sitosterol increased, avenasterol was unchanged, and cholestanol decreased (-6.2+/-0.7%, P<0.001), respectively. The 1980 synthesis and absorption markers were interrelated with respective values 21 years later in all age groups and quartiles (e.g. lathosterol, total population 1980 vs. 2001 r=0.460, cholestanol 1980 vs. 2001 r=0.593, P<0.001 for both). Synthesis markers were highest in the first and lowest in the fourth quartile both in 1980 and 2001 (e.g. 2001, desmosterol, quartile 1, 99+/-9, quartile 4, 83+/-2 microg/mg of cholesterol, P<0.05).
Cholesterol metabolism is significantly tracked in adolescent males over the follow-up of 21 years. Thus, high cholesterol synthesis and low absorption characterize subjects with the lowest cholestanol quartile, while those with the highest quartile have low synthesis and high absorption in both adolescence and later in young adult life.
为了展示胆固醇代谢的追踪情况，相隔21年测量了反映胆固醇合成的血清胆甾烷醇、羊毛甾醇和链甾醇以及反映胆固醇吸收的胆烷醇、菜油甾醇、燕麦甾醇和谷甾醇与胆固醇的比值。
在最初包括参与芬兰年轻人心血管风险研究的12岁（n = 162）、15岁（n = 158）和18岁（n = 148）男性的随机人群样本中，于1980年和2001年用气液色谱法测量血清甾醇和角鲨烯。根据1980年的胆烷醇值定义了表示胆固醇吸收从低到高的胆烷醇四分位数。仅最年长年龄组的血清胆固醇升高，但随访后所有年龄组的合成标志物（除羊毛甾醇外）均升高（例如链甾醇，总体人群升高47.3±2.6%（标准误），P<0.001）。菜油甾醇（升高69.0±3.0%，P<0.001）和谷甾醇升高，燕麦甾醇不变，胆烷醇降低（降低6.2±0.7%，P<0.001）。1980年的合成和吸收标志物与21年后所有年龄组和四分位数的相应值相关（例如链甾醇，总体人群1980年与2001年r = 0.460，胆烷醇1980年与2001年r = 0.593，两者P<0.001）。1980年和2001年合成标志物在第一四分位数最高，在第四四分位数最低（例如2001年，羊毛甾醇，第一四分位数，99±9，第四四分位数，83±2微克/毫克胆固醇，P<0.05）。
在21年的随访中，青少年男性的胆固醇代谢有显著的追踪情况。因此，胆烷醇四分位数最低的受试者具有高胆固醇合成和低吸收的特征，而四分位数最高的受试者在青春期及成年早期均具有低合成和高吸收的特征。
